ID K9FVL6_PEND2 Unreviewed; 7066 AA.
AC K9FVL6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=PDIG_39590 {ECO:0000313|EMBL:EKV13184.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV13184.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV13184.1}.
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DR EMBL; AKCT01000166; EKV13184.1; -; Genomic_DNA.
DR STRING; 1170229.K9FVL6; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_222946_0_0_1; -.
DR InParanoid; K9FVL6; -.
DR OMA; MIEFEQT; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 5.
DR CDD; cd19542; CT_NRPS-like; 2.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882}.
FT DOMAIN 578..654
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1112..1188
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2230..2306
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3780..3856
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4874..4950
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6411..6487
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 7066 AA; 781915 MW; F76831B8D7870A9B CRC64;
MQSPNDLTKS ATMQDIHQIW SWNATVPEAG ETCIHTLITD KALQQPDALA VDAWDGKWTY
GELEDTSTKL ALRLLDLGVG SGTNVAICFE KSKYTPLAML AVMKAGGASI ALDPSQPQTR
LQSITNQVDP TVILCSTTKS QLAKSIITES AVALTIDEKS LSEMNSEPDS VARLPEVSLD
NNLYVVFTSG STGTPKGVVV THLNYSSAIL HQQEAHGFKS TSRVYDFASY AFDVCWSNLI
HTLTIGACLC IPSEQDRKDN LVESIRSLCA THVDVTPSVA RLIPDSLLCN IETLVLGGEK
LSAELARHLS SLVTLKNPYG PSECTPTSTI ATIRPDDDDS KISSIGRGLG VNTWVVDSEN
EEILVPIGQI GELLLEGYLL GNGYLNDQTK TTAAFVNDPP FLLNGGDGPG QPGRRGRLYK
TGDLVRYDKD GNLTFIGRKD TQVKINGQRV ELGDIEHHIH RHTPQGIVSV GQIAVEIISP
KTGSNAVLAA FLEVDLGAED VGTEEQLFSK TEKMMSNLRS NLARDVPSYM LPAVFIPVRN
FPLSPTGKTD RRQLRAIGET MDLTALAGFG AAPNEAHTPL TLREKQLRRL WGSVLRVDES
LIALDDNFLQ RACNSDAAMK LVTAAQREGL SLSVAIVLKY PLLQEMAQVV ETVEQEQTQE
IMPFELLSND VDLDLALREA AASCNVQQNQ IHEMYPCNPL QEGMISLSAK REGDYIMQYT
LELHHQCDIE RLGKAWATVV ATTPILRTRI VDITSQGLVQ AVLNEQWSSS SIQRRTLSQA
RDHKHQFGLG MPLGRFEIVT GDSSDYKYYF VWTLHHAMYD GWSLQLLLKK LENEYAGKAD
AQSNSPDFKR FIRHVSTRNS EKTHSFWAEQ FQDVEAQIFP SLPSVDYQPR SDKLYTHSVD
GIKWPKNGIT PSTTIRAAYS ILISSLTNSP DVVFGSITTG RQAAVDAVEE LIAPTIATVP
VRVSIDSKDD LGQFLQRIQS QAADMIEFEQ TGLHQIRRIN ADAELACQFQ TLLVVQPTEG
SATAPSDIFI NIADDIRKGD GNSAAELGTY SLTMECLLNK NGLDLHMNYC SAVISEHQVR
RLSQQFEHVL GQICHLTEII HRQRTTLESL RQPTTETERQ MQRIWAQVLN HDQALIGLDY
NFFQLGGDSI AAMQVVTEAR KLGLRLAVSD IFRRPKLQDV AKKACESGLH FYGEEQLMKD
SEIRVNGDTE HTKLPDDVKA VAGDEPQQVM IWEGMFDKEV YGIIDDVQLE KIGRDFIGRT
SMYNGNQMDN VELNEWLEDT IATIRSSGST ANILELGSGS GMILFNLANG LHSYVGLDPS
EKAVDFVCST VKSIPQLAER VYNIKGTADN INSLGVPISA NMVIVNSVAQ YFPSLDYLLK
IIDDLVQLKT ARTIFFGDIR SYALFREFQV TRALHVAGDA ATEDEIRQMM VSKDQVELEL
LVDPAFFTSL VDRFPGIVEH VEILPKRMKS TNELSAYRYA AVVHLKDLSQ TAQPLQVYDI
QKESWIDYSG RQLNRQSLLQ LVQDSFFRDP SPSLVVAVCN IPYSMTVYER HVIEWLDSGL
TAGPDAENWL SSIRQTSQEC SSLSAFDLQQ IAEQTGWQVE ISWSRQFSQR GGLDAIFHRR
HSREDGTSRT LFNFPTDYQG RPSQSLSNWP LQRKQQGEEK QITLGDVSTV CKEDLHDIWT
WNEVLPGVLE ACVHDLISDT VRAQPQSPAI CAWDGEWSYI ELDDLSSRLA HALAPFGVTN
TVVPICFEKS KWTPVAMLAV MKAGAASITL DASQPLGRLR SIISQTDPRV ILSSASKQDL
AVQLTRAPNL VLDQHSISTM HITAEPLPTV DPSSKLYIVF TSGTTGVPKG AIITHSNFSS
AIRYQQDAHG FKSTSRIYDF ASYAFDVSWS NFIHALTIGA CLCIPSDEDR RDDLAGSLER
LGATHADMTP SAASLLPEKS FKRLETVVLG GEKLSVESAQ RWSSLVSLKN PYGPSECTPT
ATIATITPTD KYKSSIGRGM GLNTWIVDTV RGSLVPVGGV GELLLEGPLV GAGYLGDDRK
TAASFVQDPQ FLLQICPQGQ ARHTRMYKTG DLVHYNPDGS LSFVGRKDAQ VKIHGQRVEL
TEIESHIRRT SKTIQVAILF TKSGLCANRV VAFVCIQGTG QTQTAADQIR LVDPKYSTHV
TAYTESAKSS LSDTLPAYMI PSIWIPLQHV PLSTSGKLDY KALKSWLDSM DAKTFSNIIT
ASDGDVELRK AETELEQAIL EACATILNIT ASKVNLDRSF IANGGDSISA MRLVAHCRAD
NVVFSVAALL KSKTLASVAS TSKIKSSSNV LGFYEEKSDS FALSPIQRWF FEQGLFKRSN
ENFDNQGFYL KVKRPILTQH IDSAISEVVQ HHSMLRARFH RNGDEWTQKT LKPDTSGLYH
FGVHHMCFAA DIERLALSRH RILDIEEGPV FSADVCHNAF GEQYLILIAH HLVVDLVSWR
VILEDIESLL GGNHLQPSFS FQVWNDMQIE RAKESSFLDP ENVLSTTGIN NNLEFWQATA
ETKNTVEDHL KYCTKIESKI TELILKDANY PFNTEPVDLL LAAVWQAFFK TFPQRDGLTI
FIEGHGREPW SSDIDLSRTV GWFTTISPIH VLKSDVHQSV ASLVRFVKDA RRLLPANGWA
YFASRYLNES GKSAFKSHDS IMEITFNYHG QFQQLENEKA MFENVTLNGV YEQGSALPAS
SLIAVEVSID RGQVTFDISA NRYINHQDCI SNWVKAISQS LKTICNELVS TEISHRTLCD
YEFLSLGYTE LNRLQERVIP EIEKLNNSTV ENVYRCLPTV DGILISQFKD PESYKTVQLF
EITSHIDDQI DMERLSLAWQ KVVANQPALR TVFIPGMDKA AAFNQVVLTQ YHAELIILHT
ASDDHTETLE MFKNLSPINY QSFKPPHRAA MCRISPSRVI CQFEMSHAIT DGASTSILAN
DLLQTYNGNL MPLNLMDTAY EFARTQLTSS FGEKLSYWKK KLSGMDPCHF PKISGASTQG
TGTSVCKIRG SLYSKIQDYC NSVEVTTASL FQTIWALSVA AYTGNDSACF GYLASGRDLP
IAGIDKSIGA FTNMLICRVN INRETEILQF VQTIHDQVVR DLEHQHCSLA SIQHELGMDS
DNSLFNSIIS YQKQDDEPVG DEGLVIKALD GEDPTEYDIV LNIGHATDHI EIVFDYSHAC
LSSIQAESVL SLMKSTAAAL VQHDSGDNQT LGSVNMVSTE DISEIWQWNS DVPVTVDDCV
HHIITRTCHE RPQAQAICAW NGDWTYAELE KLSDRLAHLL VSYGVGPEVV VPLCFEKSKW
TPIAMMAVMK AGGASVAMDS TQPEERLRAI VNQVKSPIIL SSFVNEQLAS RLISELPSPT
KVLTISDKEL EMLNVPSGSQ LPHVKPSDTL YVVFTSGSTG VPKGVAVTHS NIASAIKHQR
HSLGFTSESR IFDFSSYMFD VVWCNLLQGL SAGSCVCIPS DNEKKTDFMA AIVRMRANIV
ILTPSAIRGL KLDALNNLCN LHFIGEPLHI DTFRSVDESV TISNLYGPTE CTTFSTVQIS
CGRQHQSITI GKGAGLNTWV ADIATGTALV PIGSAGELLL EGPLVAAGYR DDAVKTAAAF
VDDPPFLLRG SVGHPGRRGR LYKTGDIVRY NSNGTLTFLG RKDSQVKING QRVEFGDIES
HINGSLLPDF SEGQALVEFV TPQGSSRPML VAFVYFGAAV TEGMDEADLL SLAKRTAISL
DERLAARIPA FMIPSAYFPL QKIAVTATGK TDRRRLREIA KDVTWDQLIA TNSHSSDRCQ
PGTEMEIQLQ ILWENVLGVE SSLIGAHDNF MRVGGDSVGA IRLASSAREL GFTLNVADIL
KNPKLSDMAK LMIRTEPSQD LSIKEFSLLK PGSDVDWAVA ETSALCGVDG NQVEDLYPCT
PLQEGLLALT TKRPGDYIIR CILELKRSTD VKKFCAAWEA VLESTPILRT RIIDIAEQGL
VQAVIKQPAQ WTSAEASRLV DFLAADDEKT TGLGMPLVRF GLVQETNKHF FVLTLHHAVY
DGWALNLVFE KLENFYAESS RHESSDFRHF VKHISSLNND AAARFWKDQL QGSEAPTFPS
LPTAMFASKS EKTISHTVEE LQWPKTDVTA FTLVRAALSL LTAAYTNSED VCFGVTSNGR
QVGLPGVERM IGPTIATVPV RVRIDREQRL HAFLTQIQHQ SIDMIAFEQF GLQQIRKSSP
DAERACDFQT LLIVQPTEET AQWQSDIIAR DIGEGAGNST GNQEVGTYAL TLECHLGPEK
LLIKANFDSN VIDELQVKRF TKQFEHVLRQ ICCSGSDLAV SDIDTTSKQD MEDIWEWNAV
VPQSVNTPVH ELISAATRRL PHVQAVCAWD GNWTYRQLDD LSNYVAHHLV TLGVGSQDIV
PLLFEKSKWM PIAMLGVMKA GAASVAVDTS QPKDRLRMII DQANPRVALS SADKLPLVQS
LTKAQSFVVD GQGIDCLSKT SLDCTLPVVD PSSRLYLVFT SGSTGVPKGV IIRHCNFASA
IKHQKEVQGI LPTSRVYDFA SYAFDVAWAN ALLTFESGAC LCIPSDADRK DNLNGSIAQL
KPTHADLTPS AALVLSKESL QQLDTLTLGG ERLLAEYATK WSQFVTVKNS YGPSECTPTA
TFTDGIGRGH DLGASIGKPA GLNTWVVDPM TGQSLVPIGS VGELFLEGPL VGAGYLGDAK
KTNAAFIHDP SFLLRGNVVG QPGRRGTLYK TGDIVRYNSD GSLTFVCRKD TQIKINGQRV
ELAEIESHMA RYTATRQVAT LLPSTGLCAS KLVAMISFTD VHYDVNEDLA ENKIELASSK
HDQLINEHIE TLQSFLRGSL PQYMIPSLWV VLYNLPMTAS GKQDNKALKS WLEKIDETVF
SKINNANGSD IFRKPDTEAE RALSKTCSIV LNMPVDKINL DKSFIANGGD SISAMRLASH
YRTAGISVSV ATLLQSKTLA DFATFSVATA ITGVSQEEHP DVPFELSPIQ QWFFDQSPFV
SQQKHDRFYN QGFYVRLRRT VGINDLESAF LSLVNQHAML RSRFQNYGGK WKQMILSRSK
RALQLNISQH LSMSEIASLA QERHRQIDIE KGPVFSVDIC LLGQQQHLVM IAHHLVTDLV
SWRVILDDLE TILNGHSLTA ALPFQVWSKL QAERAASSTL KPHNLLSTDG VHNNLEFWKY
THDTPNCLAD HRLRSVTIDR ETTAVLLGEA NKAMNTEPVE ILLSAVWDAF LRTFPQRNSL
TIFNEGHGRE TWSDEIDLSS TVGWFTTLSP INIYRTNATN ETDMVRLVKD ARRSLPANGW
SYFTSRYLNP DGQRAFDSHN TVSEVVFNYH GQFQQLESHQ ALFEDIDLVG VREQGRLISA
GSLFNIEVAI EAMQAHFEFS VNQNIAHQSL IDQWIDQIQP SLERICLVLL EANPTHTLCD
FKFISLDYQR LDDLTSRLLP EIESINHSTV EEIFSCSPIV DGMLLSQIKQ PESYKTLQQY
EVLSSHDHPI CLDTLKIAWQ KIISRQPALR TVFTAGLDGS TAFYQALLKE HAGDVIVVEA
KTKEEALKTF SRLPKLDYQQ AKPPHRLTLC QTSDDKVFCQ IEMSHAITDG ASSSILIKDL
INAYGDNLSS TDLVKTTREF ASHLLAKPQS QKISYWNTKL KGLEPCRFPS LSDLRREKHE
FSSEIGVIVE DKMFAQIQNY CINNQVTPAS LLKSAWALTL STYVQNQSVC FGYLASGRDL
PIAGMDESVG AYTNIMVCRA DLDWQQPNVA FVRQFQHQLM QDLSFQHISL ASIQHELGLA
SDQQLFNSIV SFQKSEDDNE QSAEDGKIRF KNIDGLDPTE YDIVLGINQR SSSIEIDLEF
SHSCLTSNQA KRVLGHLESN IAAILHNEPP ALIGPQDELD IWSWNSTVPD MVKICVHDLI
SEVVFRQPDA PAVCSWDGDF TYAELDSFAT RLANSLGKMG IGRGSIVPIC FEKSKWTPVA
MLAVMKTGAA SVTMDASQPE ERLRSIVAQV DAKLVISSTL KVELAARLTA TTVLVIDRSS
MEAMADNTPL AAVDPTNIIY IVFTSGSTGT PKGVIITHTN YSSAIKYQQS EHGFKSSSRV
FDFASYAFDV SWSNFLHTLT IGACLCIPSD DDRKNDPVGA IDRLRCTHVD MTPSAASVLP
ASTLAKLDTI VLGGEKLSLE HAQRWSALTS VRNPYGPSEC TPTSTITEIN SAEISKGKVS
IGKGVGLNTW IVDPATAQHL MPIGIPGELL LEGPLVGAGY LGDPVKTASA FIEDPEFLVK
GAGPGIPGRR GRLYRTGDLV TYNTDGSLSF VGRRDTQIKI NGQRVELGDI ESHVSANLVS
HDSAQVAVEV VSPQASSNSI LVAFVSFDDL KSINLNDEEL LARTKAATEG IRDKLVTQIP
SYMVPSVYIP VAVFPTTATG KTDRRRLREM ASSLTLEQLT SINPAQQQYQ PPTTPLEVAL
RELWISVLKL GSRKISTADN FLELGGDSID AMRLVGTARD HGLSLSVVDI FKYPKFSDMA
ALLRSLDKPQ SEEPEVFQPT SLLSKDHNKD QILSRLVDFG IELGNVEDIL PVTDHQARSI
AMTHSASRDL LLYHTLDGKG VPNMRKMRAV CDELVNRYDL MRTLFIAYKD SFLQVVLKAF
PVDITVLTSE NASLEECTEE LRLRDRDDEL LYGSLLTKIA ILHQIRDNEY RLVVRMSHAQ
HDGMSLMKMW NAFEEMYGDG SDDSFHIPSD TSFQEKSKAS FSNYMHAVAG TSLEQAKSHW
RRLLNGSSMT NLKPHASHAL TFGEGPCVTR HVPKSIAQGT GFTFSTVLKA AWAYVLAKHL
ANDDVVFCNL THGRGLPGTQ DVFGACVNII PTRVSFTDGW TVYDLLSALN TQQIANMEHE
NIGTRQIVRG CTTWPKWTYA GSIVYHHDFD DGEHIAHGRS MHVEQELDLS HGKVDMTDVH
ITSKPDNNMF QIELDFAPGV VSERDAELLT AKLTDTIIVF CNVMDMPLLS PNEIRDLRTT
TLLPSEKPLS AIPTNEQLIF ASISPTEMEW ALESAWSDTF NCSLSPQLKA GETIFDLGGD
LVSASLISAH MERQGYVLSV EDVLGNPTWF SQLTLLTKRS LRDVDV
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