ID K9G1D5_PEND2 Unreviewed; 992 AA.
AC K9G1D5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=FAD-binding PCMH-type domain-containing protein {ECO:0000259|PROSITE:PS51387};
GN ORFNames=PDIG_31450 {ECO:0000313|EMBL:EKV14692.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV14692.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00005466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV14692.1}.
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DR EMBL; AKCT01000131; EKV14692.1; -; Genomic_DNA.
DR AlphaFoldDB; K9G1D5; -.
DR STRING; 1170229.K9G1D5; -.
DR eggNOG; KOG1712; Eukaryota.
DR HOGENOM; CLU_003324_0_0_1; -.
DR InParanoid; K9G1D5; -.
DR OMA; VFETHAA; -.
DR OrthoDB; 1608525at2759; -.
DR UniPathway; UPA00057; UER00099.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:InterPro.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:InterPro.
DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.40.462.20; -; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005919; Pmev_kin_anim.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR PANTHER; PTHR42973; BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED; 1.
DR PANTHER; PTHR42973:SF25; PHOSPHOMEVALONATE KINASE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF04275; P-mevalo_kinase; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882}.
FT DOMAIN 146..338
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 740..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 108093 MW; BC43D07C612BFEDA CRC64;
MCDMKPKARF IERALEMLVE RPEGALVVMF HHDETLHLEG LVCHRTASFP TGAVCVADDD
EVLDSFAPFM TEFVMQDVEA EMAIRVEWRN VCRALGRREE AHPDRLIFNS PNIMVAFTHD
ATALPELTAQ VPLLEGDKPV KNWEARLHYP ASIVRPTEVR HIQHCVQWAL KHGVSLAVVG
GGHSGHCLRS NVVSVDMGAF DKVHVLTAED GGQESGPDSV ALIVAEAGCK TGDIVRKTMA
AGLTVPLGAR PSVGAGLWLQ GGIGHLARMY GLTCDSIIGA VMVSVGSGQA LCIGCVPSEH
WPAGAVCPTN ETDLLWAIKG AGTNFGIVVS VTFKAYAAPV FSARNWVVPL SDNLEARRRL
QDFDDLVAGK LPQECSADAY LYWDMGKLRL GVTLFESSTT GLTSETPTST DAPIETILGP
EGNFQVVDGV GLFETEMYMS RMDGGHASSK TSSFKRCLFL TRIGAPNIAK ILVTAIETRP
SPLSYLYLLQ GGRVIGDVPA DATAFGCRDW EFACVVTGVW PRDQDGSEIA RTAVQWVYNV
ASNLLPVSSG VYGADLGPDP RDTALAAKTF GPNLLRLARL KHISDPLNVL AYACPLPKTP
IKQKLIVLVT GESCAGKDHC AEIWVSAFLT CSRKSLIARV VSISDETKRE YAEATGADFN
RLLRDRLYKE RHRAALTTFF QGQVQYRPRL PEEHFLSVVY GARDVDVLLI TGMRDEAPVA
VFSHLVSHSR LIDVRINASK ETRRARQGHR GLNAEGNDTN DNNDRRPKLK SLNYRPSLIF
NNDATGNETV KRFADDCLLP FLNEDLQQLA NMVRPVPNFP HPGVKFRHVL NISQQPGGLA
LCTSLLQTHF TGDWAKVDMI VSCETGGFIY ASVLALQVDV PLALIREAGK LPPPTVSVPK
STSHISSTSN PNEKRIEIER DLIPRGASVV VVDDVLASGN TLCAVLQLLG EVGIADVSIM
VVAEFPFHRG RELLRQHGFG VNIQSLLVFD GA
//
