ID K9G231_PEND2 Unreviewed; 377 AA.
AC K9G231;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Sterol 24-c-methyltransferase, putative {ECO:0000313|EMBL:EKV08903.1};
GN ORFNames=PDIG_67670 {ECO:0000313|EMBL:EKV08903.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV08903.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV08903.1}.
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DR EMBL; AKCT01000249; EKV08903.1; -; Genomic_DNA.
DR AlphaFoldDB; K9G231; -.
DR SMR; K9G231; -.
DR STRING; 1170229.K9G231; -.
DR eggNOG; KOG1269; Eukaryota.
DR HOGENOM; CLU_039068_5_3_1; -.
DR InParanoid; K9G231; -.
DR OMA; AFNKAMH; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901617; P:organic hydroxy compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 81..376
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 377 AA; 42038 MW; 05872ADF14859D84 CRC64;
MAPSVLERED KARDAAFNKA LHGESAKAQG GLAALRGKDA AAQKAAVDEY FKHWDNQSAA
NETPEIREAR KAQYATLTRH YYNLATDFYE YGWGSSFHFC RFAYGEPFLQ AIARHEHYLA
LQAGITEDMK VLDVGCGVGG PAREIVKFTG AHVTGLNNND YQIDRATHYA HKQGLSDKMA
FVKGDFMQMS FPDNSFDAVY AIEATVHAPE LVGVYSEIFR VLKPGGTFAV YEWLMTDEYN
NDDPEHRRIR LGIEQGDGIS NMVRISEGLE AMKNAGFELK HHEDLAARPD PIPWYYPLAG
SFKHMASAWD FFTIARMTWW GRGLAHRFVG AGESIGLFPK GSQKTADSLA LAADCLVEGA
QKNLFTPMYL MVGKKPE
//
