ID K9IPU0_DESRO Unreviewed; 509 AA.
AC K9IPU0;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative low-density lipoprotein receptor-related protein 3 {ECO:0000313|EMBL:JAA50275.1};
DE Flags: Fragment;
OS Desmodus rotundus (Vampire bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Phyllostomidae;
OC Desmodontinae; Desmodus.
OX NCBI_TaxID=9430 {ECO:0000313|EMBL:JAA50275.1};
RN [1] {ECO:0000313|EMBL:JAA50275.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Salivary gland {ECO:0000313|EMBL:JAA50275.1};
RA Francischetti I.M.B., Assumpcao T.C.F., Ma D., Vicente E.C.,
RA Ribeiro J.M.C.;
RT "The Vampirome: Transcriptome and Proteome Analysis of the Submandibular
RT and Accessory Glands of the Vampire Bat and Vector of Human Rabies,
RT Desmodus rotundus.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GABZ01003250; JAA50275.1; -; mRNA.
DR AlphaFoldDB; K9IPU0; -.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF22; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00192; LDLa; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 2: Evidence at transcript level;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Lipoprotein {ECO:0000313|EMBL:JAA50275.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:JAA50275.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 265..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..133
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 405..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 205..220
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 223..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 230..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 242..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:JAA50275.1"
FT NON_TER 509
FT /evidence="ECO:0000313|EMBL:JAA50275.1"
SQ SEQUENCE 509 AA; 55215 MW; 8EF8AFCEF9B888A0 CRC64;
RCDGTQDCGD GSDEAGCPDL ACGRRLGSFY GSFASPDLFG AARGPSDLHC TWLVDTQDQR
RVLLQLELRL GYDDYVQVYE GLGERGDRLL QTLSYRSNHR PVSLEAAQGR LTVAYHARAR
SAGHGFNATY QVKGYCLPWE QPCGSSTEGV VDDTGEQGCF LESQRCDGWW HCASGRDEQG
CPACPPDQYP CEGGSGLCYT PADRCNNQKS CPDGADEKNC FSCQPGTFHC GTNLCIFETW
RCDGQEDCQD GSDEHGCLAA VPRKVITAAL IGSLVCGLLL VIALGCAFKL YSLRTQEYRA
FETQMTRLEA EFVRREAPPS YGQLIAQGLI PPVEDFPVYS ASQASMLQNL RTAMRRQMRR
HASRRGPSRR RLGRLWNRLF HRPRAPRGQI PLLTAARTSQ TVLGDGLLQP APGAALDPPA
PLTDTGSPGA AGDESPTAPS HALEVGPSVV PTSGLQDPEY RPVDKDRKAC RDPLADSPAP
VDTSREPRSA QDPHPPPPAA SSTQGPHPP
//
