ID   K9LQR4_HYPPE            Unreviewed;       386 AA.
AC   K9LQR4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AFN26935.1};
GN   Name=PKS1 {ECO:0000313|EMBL:AFN26935.1};
OS   Hypericum perforatum (St. John's wort).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Hypericaceae; Hypericeae; Hypericum.
OX   NCBI_TaxID=65561 {ECO:0000313|EMBL:AFN26935.1};
RN   [1] {ECO:0000313|EMBL:AFN26935.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Karppinen K.;
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC       ECO:0000256|RuleBase:RU003633}.
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DR   EMBL; JQ073294; AFN26935.1; -; mRNA.
DR   AlphaFoldDB; K9LQR4; -.
DR   SMR; K9LQR4; -.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   2: Evidence at transcript level;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003633};
KW   Transferase {ECO:0000256|RuleBase:RU003633}.
FT   DOMAIN          17..231
FT                   /note="Chalcone/stilbene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          241..384
FT                   /note="Chalcone/stilbene synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        167
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   386 AA;  42432 MW;  23F5AB4A3BBDA870 CRC64;
     MSNLETNGSS RNGRAPTPGK ATVLAMGKAF PKQHVPQECL VEKFISDTKC TDAAIKEKLE
     RLCETTTVKT RYTVMCKEVL DKYPELAVEG SPTIRQRFEI ANSAVVEMAI EASHACIKEW
     GRPISEITHV VYVSSSELRL PGGDLYLASE LGLRTDVRRV MLYFLGCYGG VTGLRVAKDI
     AENNPGSRVL LTTSETTILA FRPPSNARPY DLVGAALFGD GAAAVIIGTN PVAGKESPFM
     ELNYATQQFL PGTQSIVDGK LHEEGINFKL GRDLPQKIED NIEEFCKKIM SEAGLTQFND
     LFWAVHPGGP EILNRVESRL GLNADKLECS RRALMDFGNV SSNTVLYVME YLREELKRKG
     SEEWGLALAF GPGITFEGVL LRSLCL
//