ID K9MBX7_9HIV1 Unreviewed; 180 AA.
AC K9MBX7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:AFU76761.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AFU76761.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AFU76761.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AFU76761.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=0086_4 {ECO:0000313|EMBL:AFU76761.1};
RX PubMed=23123038; DOI=10.1016/j.virol.2012.10.009;
RA Baalwa J., Wang S., Parrish N.F., Decker J.M., Keele B.F., Learn G.H.,
RA Yue L., Ruzagira E., Ssemwanga D., Kamali A., Amornkul P.N., Price M.A.,
RA Kappes J.C., Karita E., Kaleebu P., Sanders E., Gilmour J., Allen S.,
RA Hunter E., Montefiori D.C., Haynes B.F., Cormier E., Hahn B.H., Shaw G.M.;
RT "Molecular identification, cloning and characterization of
RT transmitted/founder HIV-1 subtype A, D and A/D infectious molecular
RT clones.";
RL Virology 436:33-48(2013).
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DR EMBL; JX877502; AFU76761.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR Pfam; PF00665; rve; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 1..33
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 43..180
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFU76761.1"
FT NON_TER 180
FT /evidence="ECO:0000313|EMBL:AFU76761.1"
SQ SEQUENCE 180 AA; 20091 MW; C19A0B7ED949B5DD CRC64;
HERYHSNWRA MASDFNLPPI VAKEIVASCD KCQLKGEAMH GQVDCSPGMW QLDCTHLEGK
IILVAVHVAS GYIEAEVIPA ETGQETAYFL LKLAGRWPVK VVHTDNGSNF TSAAFKAACW
WANIQQEFGI PYNPQSQGVV ESMNKELKKI IGQVREQAEH LRTAVQMAVF IHNFKRKGGI
//
