ID K9UVE2_9CYAN Unreviewed; 768 AA.
AC K9UVE2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Kef-type potassium/proton antiporter, CPA2 family {ECO:0000313|EMBL:AFY99520.1};
GN ORFNames=Cal6303_0443 {ECO:0000313|EMBL:AFY99520.1};
OS Calothrix sp. PCC 6303.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC Calothrix.
OX NCBI_TaxID=1170562 {ECO:0000313|EMBL:AFY99520.1, ECO:0000313|Proteomes:UP000010477};
RN [1] {ECO:0000313|EMBL:AFY99520.1, ECO:0000313|Proteomes:UP000010477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6303 {ECO:0000313|EMBL:AFY99520.1,
RC ECO:0000313|Proteomes:UP000010477};
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Chen A., Kyrpides N.,
RA Mavromatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Pati A.,
RA Goodwin L., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T., Kerfeld C.A.;
RT "Finished chromosome of genome of Calothrix sp. PCC 6303.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003610; AFY99520.1; -; Genomic_DNA.
DR RefSeq; WP_015196176.1; NC_019751.1.
DR AlphaFoldDB; K9UVE2; -.
DR STRING; 1170562.Cal6303_0443; -.
DR KEGG; calt:Cal6303_0443; -.
DR PATRIC; fig|1170562.3.peg.476; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG1226; Bacteria.
DR HOGENOM; CLU_005126_9_0_3; -.
DR OrthoDB; 9793589at2; -.
DR Proteomes; UP000010477; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR045158; KEA4/5/6-like.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR16254; POTASSIUM/PROTON ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR16254:SF30; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010477};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 417..539
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 581..666
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 679..749
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 768 AA; 83602 MW; E4A2858B9E5974E8 CRC64;
MQEDFRLILD LVSVLAVAAC GGLLASLLKQ PVLLGYIIGG VVVGPTGLGL IKELIQVETL
AQFGVAFLLF ALGVEFSFSE IKKVRGVALG GGAAQIILTI LVTVLVCGVT GAWGALPAKG
VFLGSILSLS STAVVLKCLM ERNETETPHG QVLLGILVVQ DLALGLMLAV LPALDKPIDQ
IGVAVLMALV KISLFAAGAV ITGKWLIPPL LRTLAKTESR ELFLLGVVVL CLSIALLTEY
LGLSIEMGAF VAGLMISEVE YADQTLSYVE PVRDIFASLF FASIGMLIDP VFLWNHLELI
LGLVALVLIG KFIIITPIVK LFGYPLKTAI IAGVGLAQIG EFSFVLASEG QVMGLVSRQI
YLIILGTTAV TLVVTPFLLR SVPIVFDWLE SIPWLKPYIS GDGKPLEIAE DTPLKDHIVI
CGYGRVGKNL VKLLQLHNLP IVVIDQSERR IQQLRDAKVP YIYGNCVSFH VLEAAGVQTA
KGMAIALPDP MSSRLTLKRA LELLPELDVV VRANSDRNIE VFYQLGAHEV VQPEFEASLE
MATHLLGDSG LSPTLIQQQM QEIRDRHYLD LRPEETEIEI SRNLQQVTQD LNRRWYTLPT
SSPLVGMTLE EADMRYLTGV SLMAIRRSSG KEIDYPDGKT KLEEGDNLLI VGANGEIAAL
NEFAQGKVAV PGENRACQWV TITQSCPVIG KTIADLDIHQ KFCVEIQSMR REGRFIRLPG
DHTDLQNHDQ LLLCGSLKAI EELRDFLAPV NLFPLGIPVV KVEETEVV
//
