ID K9X8V8_9NOST Unreviewed; 3297 AA.
AC K9X8V8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:AFZ28072.1};
GN ORFNames=Cylst_6101 {ECO:0000313|EMBL:AFZ28072.1};
OS Cylindrospermum stagnale PCC 7417.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC Cylindrospermum.
OX NCBI_TaxID=56107 {ECO:0000313|EMBL:AFZ28072.1, ECO:0000313|Proteomes:UP000010475};
RN [1] {ECO:0000313|EMBL:AFZ28072.1, ECO:0000313|Proteomes:UP000010475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7417 {ECO:0000313|EMBL:AFZ28072.1,
RC ECO:0000313|Proteomes:UP000010475};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Chen A., Kyrpides N.,
RA Mavromatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Pati A.,
RA Goodwin L., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T., Kerfeld C.A.;
RT "Finished chromosome of genome of Cylindrospermum stagnale PCC 7417.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003642; AFZ28072.1; -; Genomic_DNA.
DR RefSeq; WP_015211304.1; NC_019757.1.
DR STRING; 56107.Cylst_6101; -.
DR KEGG; csg:Cylst_6101; -.
DR PATRIC; fig|56107.3.peg.6706; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_11_0_3; -.
DR OrthoDB; 9757538at2; -.
DR Proteomes; UP000010475; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 5.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010475}.
FT DOMAIN 782..857
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1849..1924
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2934..3009
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3297 AA; 372942 MW; 4186B5CCFCA19FF6 CRC64;
MNIEDTYLES CSNAERFWRD FLRGFTAPLK LSAIANPTSS PPCRGTQEIR LTSSKTLDLT
NLTQNYQLSL YSLIQGAMAL LLSHYSGETD ILFGATRACR QADSKELCLN ILPVRVSIHP
GTSVLSWLRE LQAQWMALQD YESISLGQIR NWSQVPPESP LFETLVILAN DGLEAELQEQ
GDYPLVLSVD AESDLLLKID YERTQFADDA IARMLGHLET IFTSLLNLPQ QSIADIPLLT
AAQRHQLLVE WNQTEANYPQ DKCIHHLFEE QVERTPDAVA VVFEQQQLTY RELNQRANQL
AQYLQTLGVQ PEVLVGICTE RSLEMIVGIL GILKAGGAYV PLDIAYPKER LAFMLSDSQV
SLLLTQQHLV EKLPEHQAKI ICLDGDGDAP AKTPEKQTAS AVKATNLAYV IYTSGSTGKP
KGVLIPHCNV VRLFAATQSW FQFNQNDIWS LFHSYAFDFS VWELWGALLY GGRLVIVPYY
VSRTPELFYN LLSQEKITVL NQTPSAFQQI LQLEESLNVQ RDLSLRYVIF GGETLNIQSL
RPWFERHGEQ SPQLVNMYGI TETTVHVTYR PLTIADLDSS RNVIGRKIPD LQQYILNSQL
QPVPIGVPGE IYIGGAGLAR GYLNRPELTA QRFILHPFSQ QPEARLYKSG DLVRYLANGD
IEYLGRLDNQ VKIRGFRIEI GEIEALLNQH SAIRETKVIA REDIPGDKRL VAYFVFSSKQ
NSPSEILNQL RQYLQQQLPD YMVPSAFVLL ESFPLTPNGK IDHRALPAPN LLGFRRPSNY
LAPRTPTEEI LANLWREVLQ VEPIGIDDNF FELGGHSLLA TQVISRIRQG LNLEVSVRSL
FEFPTIAQLA PQISTTPQTD SLTLPPIPPR KHQGTLPLSF AQQRLWFLDQ LQPNSTAYHL
SYIFQIQGTL NLYALQQSLG EIIQRHEILH TNFPAVDGQA IQVIVANIAF NLPIIDLQSL
PVTQQKLETQ RIANQEAQQP FNLAQDPLLR LKLLRLSPAE NLLLLNIHHI IFDGWSFGVL
FTELKTLYPA FCEAQPSQLP QLPIQYADFT LWQHQWLSGE VLDSQLHYWK QQLGGTLPLL
QLPTDHPRPP VQTYQGASFS LILSPELTAN IKSLSQQEGV TLFMTLLAAF KILLYRYTGQ
ENVIVGTPIA GRNRREIESL IGFFVNTLAL RTDLGGNPSF RELLGRVRQV CLEAYTHQDL
PFEQLVTALQ PERHLSHTPV FQVMFALDNA PMGEFALPGL AVTPLASPIQ TAKFDLTLSM
EERNGQLTGE WEYNTDLFEA ATIERMIKHF QTLLSGITAH PNQSIWKLPL LTEAEKHQLL
IEWNQTEADY PQDKCIHQLF EEQVERTPDA IAVVFEQQQL TYRELNQRAN QLAHYLQKRG
VGTEALVGIC VERSLEMIIA VLSTLKAGGA YLPLDPAYPQ ERLAFMVQDA QVSILLTQTE
LLPSLPVFST QLINLDTDWQ QITQFPSSNP INTQLQPKNL AYIIYTSGST GQPKGVMIQH
CSLVNTYFAW ETIYQLRTTT TSHLQMASFS FDVFSGDLIR TLCSGGKLVL CPRHLLLSPE
LLYGLMQKEK VDCADFVPAV LRNLVQYLES SQQRLDFMRL LICGSDSWSS AEYQKILQLS
SSQTRLINSY GLTEATIDSS YFETTAKNLA LNQLLPIGRP FPNTQLCILD KHLQPVPIGV
AGELYIGGVN LARGYRHRTE LTTNKFIPNP FSKNPGERLY KTGDLVRYLP DGNIEFLQRI
DNQVKIRGFR IEIGEIEATI NQNHNVTKAV VIVREDIPDD KRLVAYVVPH STETSVLELR
NFLKSKLPGY MIPSAFVLLE EIPLTPNGKI DHRALPAPNV SFSQSNYVAP RTPTEEILAN
LWREILKVEL ISIHDNFFEL GGHSLLATQV ISRIRQVFNR EIPLRLLFES PNIAQLSSQL
GKTKSLPVPP IQPRKQPENL PLSFAQQRLW FLDQLEPNST AYNMPFTLRL QGLLNIHALS
QTIAEIIQRH QILHTNFAAV AGQLTQVIND HNAFSLPIID LQSLPNFQRE AEAQKIANEE
AQQPFNLVHD SLFRVKLLRL NEAEHLLLLN IHHIIFDGWS FGVLFAELKA VYAAFCLGHS
LPLQQLPIQY ADFALWQRQW LSGQVLDSQL NYWKRQLGGT LPVLDLPTDY PRPPMQTYQG
AAKSFVLSLE LTASIKSLCQ KEGATLFMTL LAAFKILLCR YSGQDDVIVG TPIAGRNRTE
IEDLIGFFVN TLALRTDLAG NPSFRELLGR VRQVCLEAYA HQDLPFEKLV EELQPERNLS
HTPLFQVWFN MINLSSDSLE LMGLKVEPVS ILETASKFDL SLYIREENQQ IHLQLVYNTL
LFNADTIQWM GMHLQRLLAG IAANPEKPIS TFPLLTKTER YELSHPCNLI RPTNSFNEFP
KQEIEQSIPA RFEQQAKKYP HNIAVKTKNY QWTYRELNLQ AHKIAQILLQ KNLNRDAKIA
LLFDHDAPMV SAILGVLKLG QIYVPLEPKY PRQRVLSILE DSLCQLVLTN NKNLADAQKI
TDGKLPIINI DDINVNDFPE EITQEISADT LAYILYTSGS TGKPKGVIQN HRNVLHFIRN
YTNNLHVSPN DKLTLFSSYS FDAAIIDIFS AILNGATLYP FNIKVEGLAH LSEWLDEQEI
TIYHSTPTVY RQFIQILPVK PSIEKTQLSK VRLVVLGGEE VVKSDVELYQ KHFSHECILV
NGLGSTESSF NLQYLIDKKT QLTQKQVPVG YPFDDTEIIL LDESGNPTDI LGEIAIRSPH
IALGYWQKPE LTKVVFLNDS EGSNKRIYRT GDLGRLRVNG AIEFLGRKDF QVKIRGFRIE
LGEIEAVLSQ HPAVQEAVVI TREVIPGEKR LVAYIIPRSN PNLNQEIGNE PFTQSQSLII
NQLKQSLKQN LPDYMVPSAF VLLDVLPLTP NGKINRRALP APDFAKFESE KYTTPTDNLE
LQLTKIWENV LGIQPIGLSD NFFDVGGHSL LAIRLFAQIE KIFGKHLALT TLFQSPTIRQ
LANVLRQEGC STSWSSLVPI QPNGSKPPFF YIHTVYGGLI HSHNLLSKMN SDQPIYGLQA
QGLDGKKPPH TCIEDMAGHY IKEIQTVQPH GPYFLGGWCA GGMIAYEIAQ QLYAQGETVE
LLVIFDAYPP KMISQSNTSS SHLSWRQTKS SLDQSILHLI DTIKRNRSLF ATLKNQQQII
SIGKKINHRI YDRIKEIIYK FYLNKNLTLP HSLRELAVRD AISQAYKNYF PQVYSGKVIF
FRAVIQPKEY ADYLKQWEEL AAGGLEIHDI PGHHDSILSE PNVRVLAEKL RACIAMH
//
