ID K9YF78_HALP7 Unreviewed; 265 AA.
AC K9YF78;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Glycine/sarcosine N-methyltransferase {ECO:0000313|EMBL:AFZ45621.1};
DE EC=2.1.1.156 {ECO:0000313|EMBL:AFZ45621.1};
GN OrderedLocusNames=PCC7418_3510 {ECO:0000313|EMBL:AFZ45621.1};
OS Halothece sp. (strain PCC 7418) (Synechococcus sp. (strain PCC 7418)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Halothecacae; Halothece cluster; Halothece.
OX NCBI_TaxID=65093 {ECO:0000313|EMBL:AFZ45621.1, ECO:0000313|Proteomes:UP000010481};
RN [1] {ECO:0000313|Proteomes:UP000010481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7418 {ECO:0000313|Proteomes:UP000010481};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Glycine N-methyltransferase family.
CC {ECO:0000256|PIRNR:PIRNR000385}.
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DR EMBL; CP003945; AFZ45621.1; -; Genomic_DNA.
DR RefSeq; WP_015227493.1; NC_019779.1.
DR AlphaFoldDB; K9YF78; -.
DR SMR; K9YF78; -.
DR STRING; 65093.PCC7418_3510; -.
DR KEGG; hao:PCC7418_3510; -.
DR PATRIC; fig|65093.3.peg.3710; -.
DR eggNOG; COG2226; Bacteria.
DR HOGENOM; CLU_069129_0_0_3; -.
DR OrthoDB; 9791837at2; -.
DR Proteomes; UP000010481; Chromosome.
DR GO; GO:0017174; F:glycine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0052730; F:sarcosine N-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.30.46.10; Glycine N-methyltransferase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR014369; Gly/Sar_N_MeTrfase.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR16458; GLYCINE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR16458:SF2; GLYCINE N-METHYLTRANSFERASE; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR PIRSF; PIRSF000385; Gly_N-mtase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51600; SAM_GNMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR000385};
KW Reference proteome {ECO:0000313|Proteomes:UP000010481};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR000385};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000385}.
FT DOMAIN 65..162
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT BINDING 28
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 36
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 45
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 69
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 90
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 116..117
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
FT BINDING 134
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PIRSR:PIRSR000385-2"
SQ SEQUENCE 265 AA; 31213 MW; DD65C73F70E44536 CRC64;
MAIKEKQVQD YGENPIEVRD SDHYQNEYIE GFVEKWDELI NWHARSSSEG EFFIKTLKEH
GAKRVLDAAT GTGFHSIRLI EAGFDVASVD GSVEMLVKAF ENATRKDQIL RTVHSDWRQV
TRHIQERFDA VICLGNSFTH LFSEEDRRKT LAEFYSVLKH DGILILDQRN YDLILDEGFK
SKHTYYYCGD NVKAEPEYVD DGLARFRYEF PDQSVYHLNM FPLRKDYVRR LLHEVGFQDI
TTYGDFQETY HQDDPDFYIH VAKKD
//
