ID K9Z8G5_CYAAP Unreviewed; 774 AA.
AC K9Z8G5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN OrderedLocusNames=Cyan10605_2808 {ECO:0000313|EMBL:AFZ54875.1};
OS Cyanobacterium aponinum (strain PCC 10605).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Geminocystaceae; Cyanobacterium.
OX NCBI_TaxID=755178 {ECO:0000313|EMBL:AFZ54875.1, ECO:0000313|Proteomes:UP000010480};
RN [1] {ECO:0000313|Proteomes:UP000010480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 10605 {ECO:0000313|Proteomes:UP000010480};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
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DR EMBL; CP003947; AFZ54875.1; -; Genomic_DNA.
DR RefSeq; WP_015220597.1; NC_019776.1.
DR AlphaFoldDB; K9Z8G5; -.
DR STRING; 755178.Cyan10605_2808; -.
DR KEGG; can:Cyan10605_2808; -.
DR PATRIC; fig|755178.3.peg.2985; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_3; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000010480; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000010480}.
FT DOMAIN 9..342
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 343..619
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 550..587
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 774 AA; 89295 MW; 906D436A6A9A41F3 CRC64;
MNSRIDFLSH LNLSQRQAVE HFCGPLLVVA GAGSGKTRAL TYRIANLIST HKVAPENILA
VTFTNKAARE MKERIELIFA QQMAEEKYGN KLELLGELEQ KQIKSKVYRR AIKDLWIGTF
HSLCAKILRY DINKYQDEKG RTWQKNFTIL DESDVQSLFK QIVTKNLNLD DKKFEPRKIR
YTISNIKNLG FTPRQYALEN PDYRGRVIAE IYEEYQNELA KNNALDFDDL LLIPVRIFQE
NESILGYWHN QFHHILVDEY QDTNQIQYNL IRLLSTNNET NKKYWNWNNR SVFVVGDADQ
SIYSFRMADF TILLNFQEDF GDNLPDQETQ TMIKLEENYR SRENILQAAN YLIEHNSQRI
DKVLKATRGE GESIYLYRGD NEREEATFVC RQIAQLVREN ADLNWGDFAI LYRINSQSRA
FEDELIKKNI PYNIVGGLKF YERKEVKDAL AYLRLIVNPA DTVSLLRIIN TPRRGIGKTT
IDNLLTASVE LGVPLWEILN DRTSVNTIAG RAAKRVNEFA QLILDCQEMM KESSAVEVLN
HILLASGYSQ DLQQQNTDEA ENRLENLNEL ANAMSQFQED NEDSSLEGFL SSASLASDLD
NLNEDNQAVS LMTLHSAKGL EFPIVFLVGF EQGLLPHNRS LRDPLELEEE RRLCYVGITR
AKEQLFITHA RERYSWGNVD YCTPSQFLDE LPPELLSSNI PPRKSFRHNI IEETPKKKSP
SQSWQEGDRL YHPTFGNGVV THLLGLGSKN TLVVQFEVGR KIINPSHTKL EKIS
//
