ID KDGD_PSEPK Reviewed; 303 AA.
AC Q88GW8;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=5-dehydro-4-deoxyglucarate dehydratase;
DE EC=4.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00694};
DE AltName: Full=5-keto-4-deoxy-glucarate dehydratase {ECO:0000255|HAMAP-Rule:MF_00694};
DE Short=KDGDH {ECO:0000255|HAMAP-Rule:MF_00694};
GN OrderedLocusNames=PP_3599;
OS Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS / KT2440).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=160488;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT "Complete genome sequence and comparative analysis of the metabolically
RT versatile Pseudomonas putida KT2440.";
RL Environ. Microbiol. 4:799-808(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate +
CC CO2 + H2O; Xref=Rhea:RHEA:24608, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:42819,
CC ChEBI:CHEBI:58136; EC=4.2.1.41; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00694};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-glucarate degradation; 2,5-
CC dioxopentanoate from D-glucarate: step 2/2. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
CC -!- SIMILARITY: Belongs to the DapA family. {ECO:0000255|HAMAP-
CC Rule:MF_00694}.
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DR EMBL; AE015451; AAN69199.1; -; Genomic_DNA.
DR RefSeq; NP_745735.1; NC_002947.4.
DR RefSeq; WP_010954445.1; NC_002947.4.
DR AlphaFoldDB; Q88GW8; -.
DR SMR; Q88GW8; -.
DR STRING; 160488.PP_3599; -.
DR PaxDb; 160488-PP_3599; -.
DR GeneID; 83679690; -.
DR KEGG; ppu:PP_3599; -.
DR PATRIC; fig|160488.4.peg.3827; -.
DR eggNOG; COG0329; Bacteria.
DR HOGENOM; CLU_049343_5_2_6; -.
DR OrthoDB; 8995637at2; -.
DR PhylomeDB; Q88GW8; -.
DR BioCyc; PPUT160488:G1G01-3836-MONOMER; -.
DR UniPathway; UPA00564; UER00628.
DR Proteomes; UP000000556; Chromosome.
DR GO; GO:0047448; F:5-dehydro-4-deoxyglucarate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042838; P:D-glucarate catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00951; KDGDH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00694; KDGDH; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR017655; Dehydro-deoxyglucarate_dehyd.
DR NCBIfam; TIGR03249; KdgD; 1.
DR PANTHER; PTHR12128:SF19; 5-DEHYDRO-4-DEOXYGLUCARATE DEHYDRATASE 2-RELATED; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..303
FT /note="5-dehydro-4-deoxyglucarate dehydratase"
FT /id="PRO_0000103234"
SQ SEQUENCE 303 AA; 32661 MW; BFF75C61AFFD9227 CRC64;
MNPQELKSIL SHGLLSFPVT DFNAQGDFNP AGYIKRLEWL APYGASALFA AGGTGEFFSL
AASEYSQVIK TAVDTCATSV PILAGVGGST RQAIEYAQEA ERLGAKGLLL LPHYLTEASQ
DGVAAHVEAV CKSVNIGVVV YNRNVCRLNA DLLEKLAERC PNLIGYKDGL GDIELMVSIR
RRLGERFSYL GGLPTAEVYA AAYKALGVPV YSSAVFNFVP KTAMDFYNAI ARDDHATVAK
LIDDFFLPYL DIRNRKAGYA VSIVKAGARI AGYDAGPVRT PLTDLTAEEY EMLAALMDKM
GPQ
//
