ID KIF28_MOUSE Reviewed; 1028 AA.
AC D3YXS5;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Kinesin-like protein KIF28 {ECO:0000305};
DE AltName: Full=Kinesin family member 28 {ECO:0000312|MGI:MGI:2686151};
DE AltName: Full=Kinesin-like protein 6;
GN Name=Kif28p {ECO:0000312|MGI:MGI:2686151};
GN Synonyms=Gm1305 {ECO:0000312|MGI:MGI:2686151},
GN Kif28 {ECO:0000312|MGI:MGI:2686151}, Klp6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Microtubule-dependent motor protein required for
CC mitochondrion morphology and transport of mitochondria in neuronal
CC cells. {ECO:0000250|UniProtKB:F8WLE0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:F8WLE0}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:F8WLE0}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; AC113977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D3YXS5; -.
DR SMR; D3YXS5; -.
DR STRING; 10090.ENSMUSP00000152770; -.
DR EPD; D3YXS5; -.
DR PaxDb; 10090-ENSMUSP00000118935; -.
DR PeptideAtlas; D3YXS5; -.
DR ProteomicsDB; 263533; -.
DR AGR; MGI:2686151; -.
DR MGI; MGI:2686151; Kif28.
DR eggNOG; KOG0245; Eukaryota.
DR InParanoid; D3YXS5; -.
DR TreeFam; TF105223; -.
DR Reactome; R-MMU-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR Reactome; R-MMU-983189; Kinesins.
DR PRO; PR:D3YXS5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; D3YXS5; Protein.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0031966; C:mitochondrial membrane; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR GO; GO:0072384; P:organelle transport along microtubule; ISS:UniProtKB.
DR CDD; cd22709; FHA_KIF28P; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Mitochondrion; Motor protein;
KW Nucleotide-binding; Reference proteome; Transport.
FT CHAIN 1..1028
FT /note="Kinesin-like protein KIF28"
FT /id="PRO_0000415570"
FT DOMAIN 11..358
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT DOMAIN 460..523
FT /note="FHA"
FT COILED 873..902
FT /evidence="ECO:0000255"
FT BINDING 114..121
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1028 AA; 114827 MW; 565C7D9F81AB5BD1 CRC64;
MGRVPVPRSD SVRVAVRVRP FSQREKNSGS QCVISMHSGN ISIRDPKNEE RVKTFTFDLT
YWSHDGFQKD EDGVLIPSDP ASKFAGQSDV FHDIGRGILD SAWRGYNATL LAYGQTGSGK
SYSMIGFGTN KGLIPRVCEE LFQAIEKQKE NLEPQVMFSM LEIYNEQIRD LLSRTKAPGG
LRVREDQQLG FFVEGLKWVP CENYAQIEKL VEQGSKIRMT ASTNMNASSS RSHMLIAIQF
KQVFLDTALT KRSSINMVDL AGSERQRSSG SEGDRLREGS RVNLSLTSLG NVISALADLA
MGKKVLHIPY RDSVLTKLLQ SALGGNSRTT LIAALSPADI CYEETLSTLR YAERAKKVRN
RAVINTCPLA RASRAENALL LGFRGAGAAE HPACFWAEQQ LGNQGTWAQL LEQARREWEE
QYEALTQEQK MVRILPHLLN VNEDPQLTGV LKFFIHNGSC DVGRAASNAI CLQGLGISDK
HASFVNLDGK VTVAPHSKCK VIVNGVPVTG RTKLQHLDRI ILGSNSAFLY VGFPSERGAE
DLSRFDYDFF QLERAAAEGV SVATLGCVSP GDDQADPSIL AVFQDYVKLM PLVVEANQMS
EELKKGLTME LKVKNLASSD SRGYDLQKEV MVKVTKQGTH EVWIWSKAKF INRKFLMEEL
YQRFLESRDS HVAQEDDPFW DPLEVVHLGS AHVWLQPLAH CMMLEEQVEF LNCDGLEEAV
LHIRITPCSP EGWAHGEEDM VIDPLELLGK RIDFQTHIVR CLGVKWLKED GSRGIQMGYG
IYDLPNTLYT KPVWKSVNPR IEETVHFAAL GASREFLDYL LTNALIVDLW GLQEGCAPLG
VSQLDVLLTG EGHIMVDTKT FSSVKDVSQI TSNQVPELYQ KLLKLEQETE LLRDVNRALR
GENVFLKASL ENAGSAPQAQ KLDNPEGATR TAAREAKQVC AQQASSDAQL ARALKVFYQG
MGVARGQLLR LRRCRPPEDD QMLRPFVHQQ SQMLKDLEDL LESSLHKLKA DVAFIVKKRK
EYLLPSQQ
//
