UniProt: L0AFJ3

Database: UniProt
Entry: L0AFJ3_NATGS

LinkDB:  L0AFJ3_NATGS 
Original site:  L0AFJ3_NATGS

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Ontology (5)   
   GO (5)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (15)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (2)   
   SMART (3)   
Literature (1)   
   PubMed (1)   
All databases (27)   

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ID   L0AFJ3_NATGS            Unreviewed;       786 AA.
AC   L0AFJ3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:ELY71895.1, ECO:0000313|EMBL:PLK19333.1};
DE   SubName: Full=Superfamily II helicase {ECO:0000313|EMBL:AFZ72586.1};
GN   OrderedLocusNames=Natgr_1375 {ECO:0000313|EMBL:AFZ72586.1};
GN   ORFNames=C490_04457 {ECO:0000313|EMBL:ELY71895.1}, CYV19_15300
GN   {ECO:0000313|EMBL:PLK19333.1};
OS   Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP
OS   104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronobacterium.
OX   NCBI_TaxID=797304 {ECO:0000313|EMBL:AFZ72586.1, ECO:0000313|Proteomes:UP000010468};
RN   [1] {ECO:0000313|EMBL:AFZ72586.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SP2 {ECO:0000313|EMBL:AFZ72586.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA   Anderson I., Woyke T.;
RT   "Complete sequence of Natronobacterium gregoryi SP2.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000010468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43098 / CCM 3738 / NCIMB 2189 / SP2
RC   {ECO:0000313|Proteomes:UP000010468};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA   Anderson I., Woyke T.;
RT   "Complete sequence of Natronobacterium gregoryi SP2.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ELY71895.1, ECO:0000313|Proteomes:UP000011613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP2 {ECO:0000313|EMBL:ELY71895.1,
RC   ECO:0000313|Proteomes:UP000011613};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [4] {ECO:0000313|EMBL:PLK19333.1, ECO:0000313|Proteomes:UP000234484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP2 {ECO:0000313|EMBL:PLK19333.1,
RC   ECO:0000313|Proteomes:UP000234484};
RC   TISSUE=Freeze-dried powder thallus {ECO:0000313|EMBL:PLK19333.1};
RA   Jiang L., He B., Kang J., Yu M., Li N., Fang Y., Tang Z., Wu P., Yao P.,
RA   Huang J.;
RT   "The characterization of oligonucleotides binding to NgAgo.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003377; AFZ72586.1; -; Genomic_DNA.
DR   EMBL; AOIC01000035; ELY71895.1; -; Genomic_DNA.
DR   EMBL; PKKI01000055; PLK19333.1; -; Genomic_DNA.
DR   RefSeq; WP_005577165.1; NZ_PKKI01000055.1.
DR   AlphaFoldDB; L0AFJ3; -.
DR   STRING; 797304.Natgr_1375; -.
DR   GeneID; 14208539; -.
DR   KEGG; nge:Natgr_1375; -.
DR   PATRIC; fig|797304.7.peg.897; -.
DR   eggNOG; arCOG00553; Archaea.
DR   HOGENOM; CLU_006553_3_1_2; -.
DR   Proteomes; UP000010468; Chromosome.
DR   Proteomes; UP000011613; Unassembled WGS sequence.
DR   Proteomes; UP000234484; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd18795; SF2_C_Ski2; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004179; Sec63-dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02889; Sec63; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00973; Sec63; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AFZ72586.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010468}.
FT   DOMAIN          28..197
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          232..424
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   786 AA;  86049 MW;  6EE382D996CD2CA7 CRC64;
     MEVAEVLPAF ADAFAFEEFN RMQRETLPAL LESDENVVAS APTASGKTAL AELAICKALD
     DGGTALFIAP LRALTNEKED DWDRFEELDY SVYVVTGERE LNSRRARHAD ILVMTPEKLD
     SATRKHDSRR YDFVTDIDVC VIDEVHLLDA DRRGSVLEVT ISRLRRLCDP RVVALSATMP
     NVDDVAAWLD APEETTFEFG EQYRPVDLNA GVKTYTHGEN SFADKYRRLY RALDLAEPHL
     REDGQALVFV SSRQDTVRAA EAARDEIAGR DIPMGARGDY DFHTESKELE NDTLRNSVLD
     GVAFHHAGLS KNDRDLVEEW FKEGHVELLF STSTLAWGVN LPARCVVIRD TKLHDPLEGE
     VDMSPLDVLQ MLGRAGRPGY DDVGYGWVVC DTAEADKYRR LLNEGKEIES RLAESLETHL
     NAEIAMGTIT DLEDVMDWLE TTFYYERGQS KPEAYDFPNL KGRVRDCLED LVARGFVETG
     EAGDLSIEAT PRGVLASKYY LRLETAASFA GLCDRTESGR ALETGDVLAA VAGATEFESV
     SARQDERDAV DAVLVGQEAE DLEPGQRKVL AILRSAASGT TPAELQSDAW VIRRNATRLL
     SALGAFLDRF VGPHAANLSS RAEARAENGV AEDAVGLTAI DGVASGRASK LAKEGLSTPG
     DVLEAGIDGL ADAGLSEGVA ERVYEGAQSL PSIEMEWGQF PETIAAGENA VHEVTVRNVG
     EPARAGITVT VNGREMTSTN SYLRDVDTVP VGVFGADAEE LEYTVSVAFP EESLLPVERS
     RTVDIR
//

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