UniProt: L0AL19

Database: UniProt
Entry: L0AL19_NATGS

LinkDB:  L0AL19_NATGS 
Original site:  L0AL19_NATGS

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Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   EMBL (3)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (10)   

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ID   L0AL19_NATGS            Unreviewed;       322 AA.
AC   L0AL19;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Nucleoside-diphosphate-sugar epimerase {ECO:0000313|EMBL:AFZ74129.1};
DE   SubName: Full=UDP-glucose 4-epimerase {ECO:0000313|EMBL:ELY63866.1};
GN   OrderedLocusNames=Natgr_2994 {ECO:0000313|EMBL:AFZ74129.1};
GN   ORFNames=C490_15072 {ECO:0000313|EMBL:ELY63866.1}, CYV19_01410
GN   {ECO:0000313|EMBL:PLK22076.1};
OS   Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP
OS   104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronobacterium.
OX   NCBI_TaxID=797304 {ECO:0000313|EMBL:AFZ74129.1, ECO:0000313|Proteomes:UP000010468};
RN   [1] {ECO:0000313|Proteomes:UP000010468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43098 / CCM 3738 / NCIMB 2189 / SP2
RC   {ECO:0000313|Proteomes:UP000010468};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA   Anderson I., Woyke T.;
RT   "Complete sequence of Natronobacterium gregoryi SP2.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AFZ74129.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SP2 {ECO:0000313|EMBL:AFZ74129.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA   Anderson I., Woyke T.;
RT   "Complete sequence of Natronobacterium gregoryi SP2.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ELY63866.1, ECO:0000313|Proteomes:UP000011613}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP2 {ECO:0000313|EMBL:ELY63866.1,
RC   ECO:0000313|Proteomes:UP000011613};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [4] {ECO:0000313|EMBL:PLK22076.1, ECO:0000313|Proteomes:UP000234484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SP2 {ECO:0000313|EMBL:PLK22076.1,
RC   ECO:0000313|Proteomes:UP000234484};
RC   TISSUE=Freeze-dried powder thallus {ECO:0000313|EMBL:PLK22076.1};
RA   Jiang L., He B., Kang J., Yu M., Li N., Fang Y., Tang Z., Wu P., Yao P.,
RA   Huang J.;
RT   "The characterization of oligonucleotides binding to NgAgo.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637}.
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DR   EMBL; CP003377; AFZ74129.1; -; Genomic_DNA.
DR   EMBL; AOIC01000111; ELY63866.1; -; Genomic_DNA.
DR   EMBL; PKKI01000002; PLK22076.1; -; Genomic_DNA.
DR   RefSeq; WP_005580757.1; NZ_PKKI01000002.1.
DR   AlphaFoldDB; L0AL19; -.
DR   STRING; 797304.Natgr_2994; -.
DR   GeneID; 14209832; -.
DR   KEGG; nge:Natgr_2994; -.
DR   PATRIC; fig|797304.7.peg.3053; -.
DR   eggNOG; arCOG01369; Archaea.
DR   HOGENOM; CLU_007383_1_7_2; -.
DR   Proteomes; UP000010468; Chromosome.
DR   Proteomes; UP000011613; Unassembled WGS sequence.
DR   Proteomes; UP000234484; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010468}.
FT   DOMAIN          11..239
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   REGION          256..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   322 AA;  34724 MW;  FB9568109E571D28 CRC64;
     MSSPAIRDKT ILVTGGAGFI GSHLVETLAP HNEVRVLDDF SSGRRASLPE PVDVYEGDVC
     DPILLQRAAH GVDLIFHQAA MVSVDESVDA PRRSNRTNVD AGLLVLEQAR QEDARVVVAS
     SAAIYGHPEA LPVPETAATE PASPYGIQKL ALDQYARRYE ELYDLPTVTL RYFNVYGPRQ
     QGPYSGVIST FLEQARADDP ITIEGDGKQT RDFVHVDDVV RANLAAATTD EVGTAYNIGT
     GERTSIDELA ETIRSATKSS SPIVHHEPRP GDVRHSGADV SRARRRLGFE PRVSLESGVR
     SLVADGESTA TSAVSWETGT HG
//

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