ID L0DKC4_SINAD Unreviewed; 959 AA.
AC L0DKC4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Sinac_5136 {ECO:0000313|EMBL:AGA29288.1};
OS Singulisphaera acidiphila (strain ATCC BAA-1392 / DSM 18658 / VKM B-2454 /
OS MOB10).
OC Bacteria; Planctomycetota; Planctomycetia; Isosphaerales; Isosphaeraceae;
OC Singulisphaera.
OX NCBI_TaxID=886293 {ECO:0000313|EMBL:AGA29288.1, ECO:0000313|Proteomes:UP000010798};
RN [1] {ECO:0000313|EMBL:AGA29288.1, ECO:0000313|Proteomes:UP000010798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1392 / DSM 18658 / VKM B-2454 / MOB10
RC {ECO:0000313|Proteomes:UP000010798};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Chertkov O.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Tindall B., Pomrenke H., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Complete sequence of chromosome of Singulisphaera acidiphila DSM 18658.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CP003364; AGA29288.1; -; Genomic_DNA.
DR RefSeq; WP_015248392.1; NZ_JH621480.1.
DR AlphaFoldDB; L0DKC4; -.
DR STRING; 886293.Sinac_5136; -.
DR KEGG; saci:Sinac_5136; -.
DR eggNOG; COG0514; Bacteria.
DR HOGENOM; CLU_001103_14_3_0; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000010798; Chromosome.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AGA29288.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010798}.
FT DOMAIN 31..199
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 223..398
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 737..817
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 715..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 105594 MW; 5238DAA8B5FE7967 CRC64;
MSVAESAIDL ERTLRERFDL EQFRPGQREV IENVVQGRDV LCVMPTGGGK SLCYQLPALL
LPRMTLVVSP LIALMKDQVD VLIQRGVRAT LLNSSLDPAE QRTRLQEIEA GQYDLVYVAP
ERFRSPRFVE AMAKIRPSLL AVDEAHCISE WGHDFRPDYA KIGLARRRIG APPCIALTAT
ATDLVRRDIA DQLDLQDPAQ FVTGFDRPNL GYAVVEARRD ADKLVALAQT LEQNRGPSVI
YASSRARCES VGQFLENQLN RSVAIYHAGL SREERHSAQD RFMSGEAEIV VATNAFGMGV
NKANIRSVIH FNMPGTLEAY YQEAGRAGRD GNSARCVLLF ALGDRFLQEM FIENEYPPAD
TVFQVFNFLR ALESDPIELT HAEIKESAGI ELNESAVGTA IKILEGAGAL EKFLPRENMA
IVRINAEADE PSLTRRLGSQ AHVQRTVVLG LEGLVNRRFG ETIYFHPDDF ATTLGLDRPA
LNRALRTLAA ELPIDYIPPF RGNAIRVIDR SRKARDLEID FTALEKRKQR EYDKLERMVR
YAQTRQCRRS YILSYFGDAS ASRVHCGHCD NCGLGDGLAT PHAGVPIDST AGREVVLKVL
SGVARAKGRF GKTVIAQMLT GSGSEKMDRW GLKHLSTYGI LAEFRQPEVV QILDALASSG
FVEYQEVDRF RPVANLAAQG WELLKGQVAH PLVLTLPDAI AAKLTNGGLE RLAAPRPAAS
AQAAPHDEDG ADAEASALAG DPLWGHLKSL RSEWAREAKQ PSYCIFTNQT LDALVRERPS
NPKELAGIKG LGPARIERHG ASLLAAIAQH ADRPVAPSPG AAPAALPKAA PALKTAPSPA
LERPLKSKTT PTEVEVRTDR SPSSSYIPTE EWTCRLIDRG FKLDEAAAIR GLDFSAILRH
LTLAARQGRK VAPEAFLDPE VLKRWDEWRA EQGNVTSPSP YRDASEAMWN LYLACRAQG
//
