ID L0DX22_THIND Unreviewed; 298 AA.
AC L0DX22;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:AGA33510.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:AGA33510.1};
GN Name=glxR [H] {ECO:0000313|EMBL:AGA33510.1};
GN OrderedLocusNames=TVNIR_1849 {ECO:0000313|EMBL:AGA33510.1};
OS Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Thioalkalivibrio.
OX NCBI_TaxID=1255043 {ECO:0000313|EMBL:AGA33510.1, ECO:0000313|Proteomes:UP000010809};
RN [1] {ECO:0000313|Proteomes:UP000010809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14787 / UNIQEM 213 / ALEN2
RC {ECO:0000313|Proteomes:UP000010809};
RA Tikhonova T.V., Pavlov A.R., Beletsky A.V., Mardanov A.V., Sorokin D.Y.,
RA Ravin N.V., Popov V.O.;
RT "Complete sequence of Thioalkalivibrio nitratireducens.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP003989; AGA33510.1; -; Genomic_DNA.
DR RefSeq; WP_015258637.1; NC_019902.2.
DR AlphaFoldDB; L0DX22; -.
DR STRING; 1255043.TVNIR_1849; -.
DR KEGG; tni:TVNIR_1849; -.
DR PATRIC; fig|1255043.3.peg.1872; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_6; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000010809; Chromosome.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AGA33510.1}.
FT DOMAIN 13..170
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 174..293
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 180
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 298 AA; 31318 MW; 0112C6134A9795C5 CRC64;
MASPKVSDDL LPVGYVGLGI MGAPMVRNLL RAGVPVHVWA RRLEQAQRLV GDGAVPEESL
ASLVRTVRVL FLNVSDTPDV EGLMLDEGGI VANARSGLIV VDHSTIDPMR ARHIAEKARE
AGVTFIDAPV SGGERGAIEG TLTLMLGGPE ADIDRIGPLL ERVGRTLTRV GDSGAGQIAK
ACNQLIVGET LVAIGEAFAL AEAAGVDPAR VREALLGGLA NSKVLQMHGQ RLLDDDFVPG
FMAHLHAKDM GIVANTAASL GLDLSGAERV RAALARALEH GHAYDDSTIL ARYCIPER
//
