ID L0H4F3_9HIV1 Unreviewed; 326 AA.
AC L0H4F3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGA93135.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGA93135.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGA93135.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCCFE_HOMER_GP41_4463 {ECO:0000313|EMBL:AGA93135.1};
RX PubMed=23055555; DOI=10.1128/JVI.01998-12;
RG the International HIV Adaptation Collaborative;
RA Carlson J.M., Brumme C.J., Martin E., Listgarten J., Brockman M.A.,
RA Le A.Q., Chui C.K., Cotton L.A., Knapp D.J., Riddler S.A., Haubrich R.,
RA Nelson G., Pfeifer N., Deziel C.E., Heckerman D., Apps R., Carrington M.,
RA Mallal S., Harrigan P.R., John M., Brumme Z.L.;
RT "Correlates of Protective Cellular Immunity Revealed by Analysis of
RT Population-Level Immune Escape Pathways in HIV-1.";
RL J. Virol. 86:13202-13216(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; JX147040; AGA93135.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AGA93135.1};
KW Virion {ECO:0000313|EMBL:AGA93135.1}.
FT TRANSMEM 167..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..207
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 208..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGA93135.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AGA93135.1"
SQ SEQUENCE 326 AA; 37389 MW; 53DD3CD9A8C666AF CRC64;
AVGLGALFLG FLGAAGSTMG AASLTLTVQA RQLLSGIVQQ QNNLLRAIEA QQHLLQLTVW
GIKQLQARVL AVERYLKDQQ LLGIWGCSGK LICTTAVPWN ASWSNRSLDY IWDNMTWMEW
EKEINNYTGL IYNLIEESQN QQEKNEQDLL ALDKWASLWN WFDITQWLWY IKIFIMIVGG
LIGLRIVFXV LSIVNRVRQG YSPLSLQTRF PTSRGPDRPE GIEGEGGEQD RDRSTRLVTG
LFALIWDDLR SLCLFSYHRL RDLLLIVTRI VELLGRRGWE ALXYWWNLLQ YWXQELXNSA
VSLXNXTAIA VAEGTDRXLE VLQRIX
//
