ID L0H6G3_9HIV1 Unreviewed; 326 AA.
AC L0H6G3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGA93850.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGA93850.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGA93850.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BCCFE_HOMER_GP41_5180 {ECO:0000313|EMBL:AGA93850.1};
RX PubMed=23055555; DOI=10.1128/JVI.01998-12;
RG the International HIV Adaptation Collaborative;
RA Carlson J.M., Brumme C.J., Martin E., Listgarten J., Brockman M.A.,
RA Le A.Q., Chui C.K., Cotton L.A., Knapp D.J., Riddler S.A., Haubrich R.,
RA Nelson G., Pfeifer N., Deziel C.E., Heckerman D., Apps R., Carrington M.,
RA Mallal S., Harrigan P.R., John M., Brumme Z.L.;
RT "Correlates of Protective Cellular Immunity Revealed by Analysis of
RT Population-Level Immune Escape Pathways in HIV-1.";
RL J. Virol. 86:13202-13216(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; JX147757; AGA93850.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AGA93850.1};
KW Virion {ECO:0000313|EMBL:AGA93850.1}.
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..208
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 208..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 113
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGA93850.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGA93850.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AGA93850.1"
SQ SEQUENCE 326 AA; 37565 MW; 961C2BB103B780F8 CRC64;
RATLGALFLG FLGAAGSTMG AASXTLTVQA RLLLSGIVQQ QNNLLKAIEA QQHLLQLTVW
GIKQLQARVL AVERYLKDQQ LMGIWGCSGK LICTTAVPWN SSWSNKSLDQ IWDNMTWMEW
EREIDNYTXI IYRLIEDSQN QQEKNEQELL ELDKWASLWN WFDITKWLWY IKIFIMIVGG
LVGLRIIFSI LSMVNRVRQG YSPLSFQTRL PAQRGPDRPE GIEEEGGDRD RDRSXPLVDG
LLALIWVDLR SLCLFSYXXL XDXLLIVTRX VELLGRRGWE TLKYWWNLLQ YWSQELKNSA
VSLLNATAIV VAEGTDRVIE ILQRXF
//
