ID L0HCM2_METFS Unreviewed; 676 AA.
AC L0HCM2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=CO-methylating acetyl-CoA synthase {ECO:0000256|ARBA:ARBA00012244};
DE EC=2.3.1.169 {ECO:0000256|ARBA:ARBA00012244};
GN OrderedLocusNames=Metfor_1453 {ECO:0000313|EMBL:AGB02487.1};
OS Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB02487.1, ECO:0000313|Proteomes:UP000010824};
RN [1] {ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA Liu W.-T., Woyke T.;
RT "Complete sequence of Methanoregula formicicum SMSP.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB02487.1, ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RX PubMed=25189582;
RA Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT Sludge Blanket Reactor.";
RL Genome Announc. 2:e00870-14(2014).
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC {ECO:0000256|ARBA:ARBA00004905}.
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DR EMBL; CP003167; AGB02487.1; -; Genomic_DNA.
DR RefSeq; WP_015285450.1; NC_019943.1.
DR AlphaFoldDB; L0HCM2; -.
DR STRING; 593750.Metfor_1453; -.
DR GeneID; 14307842; -.
DR KEGG; mfo:Metfor_1453; -.
DR eggNOG; arCOG04360; Archaea.
DR HOGENOM; CLU_378422_0_0_2; -.
DR InParanoid; L0HCM2; -.
DR OrthoDB; 69951at2157; -.
DR UniPathway; UPA00642; -.
DR Proteomes; UP000010824; Chromosome.
DR GO; GO:0018492; F:carbon-monoxide dehydrogenase (acceptor) activity; IEA:InterPro.
DR GO; GO:0043884; F:CO-methylating acetyl-CoA synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.2030; -; 1.
DR Gene3D; 3.30.1650.10; Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3; 1.
DR Gene3D; 3.40.1470.10; Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5; 1.
DR Gene3D; 3.40.970.20; Carbon monoxide dehydrogenase alpha subunit. Chain D, domain 4; 1.
DR InterPro; IPR045822; ACS_CODH_B_C.
DR InterPro; IPR004461; CO_DH/Ac-CoA_synth_bsu.
DR InterPro; IPR038571; CO_DH/Ac-CoA_synth_bsu_3_sf.
DR InterPro; IPR016099; Prismane-like_a/b-sand.
DR InterPro; IPR011254; Prismane-like_sf.
DR NCBIfam; TIGR00316; cdhC; 1.
DR NCBIfam; NF040764; CODH_ACS_al_bet; 1.
DR PANTHER; PTHR42281; -; 1.
DR PANTHER; PTHR42281:SF1; ACETYL-COA DECARBONYLASE_SYNTHASE COMPLEX SUBUNIT BETA 1; 1.
DR Pfam; PF19436; ACS_CODH_B_C; 1.
DR Pfam; PF03598; CdhC; 1.
DR SUPFAM; SSF56821; Prismane protein-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Reference proteome {ECO:0000313|Proteomes:UP000010824};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 433..676
FT /note="CO dehydrogenase/acetyl-CoA synthase complex beta
FT subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19436"
SQ SEQUENCE 676 AA; 73475 MW; 71918485DC61CA24 CRC64;
MTDVESAKKH GEEALKTRIA SIQKPFSYEE TAYHLPISYA LTGVAVHDRA AAEDVLKKTA
NNPIVASECL LAEQTAVQGK EPAPYTGFIS DTVIRKLGYS LVDGSILGLA LIVGTPKGEG
SAAAICRELQ EKYMLTFLAG NVVPSLSGAG VKVGLDYRLI PLGSSPFYGI HFVDIVARVA
MMFGGVTPGD MHRLLAYAAE RAKAIVIVFP GLTDEEIALV DGMRVLGFPI LSLGGYENAT
WVPATPGDVV RQGMELKGIK VNVTAIPIPM SCSPAFEGKS IRKEEMYVEF GGGRSTAFEL
LRMREPSEIE DGKVTVIGPE IDAMKEGSAN PLGIIIEVAG KAMKKDYEPV LERRIHNFVN
YGEGSWHVAQ RDLIWVRISK EAVAKGVKIE HIGKLLASKF RMDFPQLLDA VAVTLITDPA
KVVEAKKEAE RVYDERDARI KGMRDSDVNT YYSCTLCQTF APNHVCVITP ERLALCGAIS
WLDGKIAYEM SPSGANQPIE KGAVINELTG EFEGVNRFVK KASHGEIERC SLYSVMEYPM
TCCGCFEAIA LMLPEVNGIM VVNREYKGMT PSGMTFSTLA GTIGGGAQTP GFAGISKNYV
LSDRFLQGEG GIERLVWMPA ALKEELKERL EKKLAERGLT GFLDKVADET TAETIEALME
FLERVGHPAL TMKPLV
//