ID L0IFW5_HALRX Unreviewed; 484 AA.
AC L0IFW5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Thiamine biosynthesis protein ThiH-like enzyme {ECO:0000313|EMBL:AGB16842.1};
GN OrderedLocusNames=Halru_2256 {ECO:0000313|EMBL:AGB16842.1};
OS Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Halovivax.
OX NCBI_TaxID=797302 {ECO:0000313|EMBL:AGB16842.1, ECO:0000313|Proteomes:UP000010846};
RN [1] {ECO:0000313|Proteomes:UP000010846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18193 / JCM 13892 / XH-70
RC {ECO:0000313|Proteomes:UP000010846};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Halovivax ruber XH-70.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP003050; AGB16842.1; -; Genomic_DNA.
DR AlphaFoldDB; L0IFW5; -.
DR STRING; 797302.Halru_2256; -.
DR KEGG; hru:Halru_2256; -.
DR eggNOG; arCOG00656; Archaea.
DR HOGENOM; CLU_040406_1_1_2; -.
DR Proteomes; UP000010846; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR045567; CofH/MnqC-like_C.
DR InterPro; IPR034405; F420.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43076:SF13; 5-AMINO-6-(D-RIBITYLAMINO)URACIL--L-TYROSINE 4-HYDROXYPHENYL TRANSFERASE; 1.
DR PANTHER; PTHR43076; FO SYNTHASE (COFH); 1.
DR Pfam; PF19288; CofH_C; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01388; 7_8-didemethyl-8-hydroxy-5-dea; 1.
DR SFLD; SFLDG01064; F420__menaquinone_cofactor_bio; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010846};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 102..386
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52558 MW; 10F619334985A40B CRC64;
MDGTAGAGDA ARPGAGDDGR AEGRAQLAGA DELDVSFDVV PETDQSFENA LGKARDGVRL
TVDDAIELLT TGTGVDGIDT RRKEQVLQAA DHRRQDIVGD EVTFVANLNN NVTTACNVGC
LFCNFKDAAH TFESDHDAPD GVEVPGFTKT PAESREIVAD AVDRGIYEVT SVSGLHPAFA
LDDEHRSILD GYVDEHGPKA AYRDLNYKRP ETYETDPGTY VDQIEAMSVD DVHVHSMTPE
EAAHARRGTD WSYEEIYRRL HEAGLDTVPG TAAEILVDEV RDVICPGKID TQGWLDAMEA
AASVGMGLTA TIMYGHVENE AHRALHLKRV RDLQARVDGA ITEFVPLSFI HQNTPLYEHG
VVSGGASRAE DELMIAVSRL FLDNIEHIQS SWVKYGDEGG LSMLACGADD FMGTILSEEI
TKRAGGEYGE FRSVADYADL ISSIGRIPVE RSTDYEQRRV VDPNESPLGP RLGPKADGTP
LIRE
//
