ID L0IRR8_9MYCO Unreviewed; 416 AA.
AC L0IRR8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:AGB20896.1};
DE Flags: Precursor;
GN ORFNames=Mycsm_00444 {ECO:0000313|EMBL:AGB20896.1};
OS Mycobacterium sp. JS623.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB20896.1, ECO:0000313|Proteomes:UP000010844};
RN [1] {ECO:0000313|Proteomes:UP000010844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003078; AGB20896.1; -; Genomic_DNA.
DR AlphaFoldDB; L0IRR8; -.
DR STRING; 212767.Mycsm_00444; -.
DR KEGG; msa:Mycsm_00444; -.
DR PATRIC; fig|710686.3.peg.443; -.
DR HOGENOM; CLU_055812_0_0_11; -.
DR Proteomes; UP000010844; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF226; HTH-TYPE TRANSCRIPTIONAL REPRESSOR RV1474C; 1.
DR Pfam; PF00440; TetR_N; 2.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 21..81
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DOMAIN 224..284
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 44..63
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT DNA_BIND 247..266
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 46313 MW; A5DF0954EF3AD178 CRC64;
MVLAMARTRP TRAEGVRRRP KDRKAQIARA SAEGFSALGY YGVSMETIAK RVGISAAALY
RHYSSKYELF RDAVLNLGQQ LVDCTFFADE ADGDAELTLH RLVSALIDTA MANRESGGLY
RWEGRYLHGD DQATLIAQMR TVHHRIQLPL MAIRPELTSR QRWTLSTAAL SVIGSIVDHR
AKLPAIQVRA LLADLADAVL AADLPDVEST VSEARPPLTG GAETPKYEAL LNESMRLFNL
KGYRDTSMED IAAAVGMPAS GIYRYFSGKS DILAAAFRRA ADRLSEEMLD IVANTPDREE
ALTAVIDAYV LRSFDRPELD YVYYTERLNM TPGDQKILRN LQRANVESWV ELVVSVRPDW
TPGQARFAVH AAMSLVIDLG RLMRYDNSAP VRAVVERLVD LTLLGRYRLR AALPAK
//
