ID   L0KAD8_HALHC            Unreviewed;       845 AA.
AC   L0KAD8;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=ATP-dependent exoDNAse (Exonuclease V), alpha subunit/helicase superfamily I member {ECO:0000313|EMBL:AGB41068.1};
GN   OrderedLocusNames=Halha_1119 {ECO:0000313|EMBL:AGB41068.1};
OS   Halobacteroides halobius (strain ATCC 35273 / DSM 5150 / MD-1).
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Halobacteroidaceae;
OC   Halobacteroides.
OX   NCBI_TaxID=748449 {ECO:0000313|EMBL:AGB41068.1, ECO:0000313|Proteomes:UP000010880};
RN   [1] {ECO:0000313|Proteomes:UP000010880}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35273 / DSM 5150 / MD-1
RC   {ECO:0000313|Proteomes:UP000010880};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Gu W.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Tindall B., Pomrenke H., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The complete genome of Halobacteroides halobius DSM 5150.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003359; AGB41068.1; -; Genomic_DNA.
DR   RefSeq; WP_015326793.1; NC_019978.1.
DR   AlphaFoldDB; L0KAD8; -.
DR   STRING; 748449.Halha_1119; -.
DR   KEGG; hhl:Halha_1119; -.
DR   PATRIC; fig|748449.3.peg.1078; -.
DR   eggNOG; COG0272; Bacteria.
DR   eggNOG; COG0507; Bacteria.
DR   HOGENOM; CLU_007524_0_1_9; -.
DR   OrthoDB; 9803432at2; -.
DR   Proteomes; UP000010880; Chromosome.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd17933; DEXSc_RecD-like; 1.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 1.10.10.2220; -; 1.
DR   Gene3D; 2.30.30.940; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029493; RecD-like_HHH.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR   Pfam; PF13604; AAA_30; 1.
DR   Pfam; PF14490; HHH_4; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Exonuclease {ECO:0000313|EMBL:AGB41068.1};
KW   Helicase {ECO:0000313|EMBL:AGB41068.1};
KW   Hydrolase {ECO:0000313|EMBL:AGB41068.1};
KW   Nuclease {ECO:0000313|EMBL:AGB41068.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010880}.
FT   DOMAIN          195..214
FT                   /note="Helix-hairpin-helix DNA-binding motif class 1"
FT                   /evidence="ECO:0000259|SMART:SM00278"
FT   DOMAIN          258..277
FT                   /note="Helix-hairpin-helix DNA-binding motif class 1"
FT                   /evidence="ECO:0000259|SMART:SM00278"
FT   DOMAIN          448..573
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   845 AA;  96972 MW;  B4B31E599ED89E7F CRC64;
     MIKGRINKIY YDKDNFYIFS IIRDNHEQLT LKGNLPTEIT KKIRPGNLVS TTGQKVWNDK
     YKNHQITVNK HNIEIEEKGA SEEDLEVLEG EVTSIVYKDD GFNVFRIDTA EDFTCVSSSP
     VFIGTQLELK GYFEKNDYGL NFNVVQSKEL PFSDKQALIH FLSSKFFKGI GKHFATKIVD
     RFGLDTLDVF RETPEKLTTI SGIGDKRAAT IIESFQEKMK IKEVIKFAVK YEITENMIFK
     LYEKYGKELI NLLQQNPYLI TELRGIGFKK ADQIAQEIGL EKDSNYRINS FLTYYLSAKS
     GGHTYFRLEE LIETIEEELE IEQAFNQVLK AYYQFEEISY TIKENGELVT KKFTKDFVLF
     TEDDLDPLTE DSKQDLSLLA KQEKLCVATE KSYQQEVDIY DKLKRINSRS ATVNLATAEI
     KELIKEQEQE QGFTYAKQQR EILEQCLKEK LVVLTGKAGT GKSTVSKGII NMFTENGDKV
     LNLAPTGKAA KRIIEVTDKR AHTIHSACYN LEFSNYDVIM VDEAGMLSTS VAHMLLKRLN
     QDHTLVLIGD VAQIPPVQPG NIFRDVINMI NSDFIAGLFV ELDEIKRQDS NSHIATVCNK
     IAEGTNPGII DYQDIRSVKK DNEQILDYIT RLIKDELEGD EVDFSNLQII SPQYNGIVGI
     NAINELIQEE FNPHDYLIET KYKKVKRHDK VMQTMNMKEL DIVNGDTLEV LRIENRAKED
     TEISREGAAD KEEIVICKLD NGLEERMIEY PKQDFIKYTT LAYCCSAHKM QGSEYPIVVY
     ILSTSHYIML NRNLLYTGLT RGKEKVYLVG QARAFYMALN NEVNQSRNTV LDLIKTHKLA
     QINQE
//