ID L0M8K4_ENTBF Unreviewed; 246 AA.
AC L0M8K4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase {ECO:0000256|HAMAP-Rule:MF_01001};
DE Short=UDP-ManNAcA transferase {ECO:0000256|HAMAP-Rule:MF_01001};
DE EC=2.4.1.180 {ECO:0000256|HAMAP-Rule:MF_01001};
GN Name=wecG {ECO:0000256|HAMAP-Rule:MF_01001};
GN Synonyms=rffM {ECO:0000256|HAMAP-Rule:MF_01001};
GN OrderedLocusNames=D782_4358 {ECO:0000313|EMBL:AGB80228.1};
OS Enterobacteriaceae bacterium (strain FGI 57).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae.
OX NCBI_TaxID=693444 {ECO:0000313|EMBL:AGB80228.1, ECO:0000313|Proteomes:UP000011002};
RN [1] {ECO:0000313|EMBL:AGB80228.1, ECO:0000313|Proteomes:UP000011002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGI 57 {ECO:0000313|EMBL:AGB80228.1,
RC ECO:0000313|Proteomes:UP000011002};
RX PubMed=23469353; DOI=10.1128/genomeA.00238-12;
RA Aylward F.O., Tremmel D.M., Bruce D.C., Chain P., Chen A.,
RA Walston Davenport K., Detter C., Han C.S., Han J., Huntemann M.,
RA Ivanova N.N., Kyrpides N.C., Markowitz V., Mavrommatis K., Nolan M.,
RA Pagani I., Pati A., Pitluck S., Deshpande S., Goodwin L., Woyke T.,
RA Currie C.R.;
RT "Complete genome of Enterobacteriaceae bacterium strain FGI 57, a strain
RT associated with leaf-cutter ant fungus gardens.";
RL Genome Announc. 1:E00238-12(2013).
CC -!- FUNCTION: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II),
CC the second lipid-linked intermediate involved in enterobacterial common
CC antigen (ECA) synthesis. {ECO:0000256|HAMAP-Rule:MF_01001}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl
CC diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-
CC ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl
CC diphosphate + H(+) + UDP; Xref=Rhea:RHEA:28366, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58223, ChEBI:CHEBI:61495, ChEBI:CHEBI:62959,
CC ChEBI:CHEBI:70731; EC=2.4.1.180; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01001};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01001}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 26 family.
CC {ECO:0000256|HAMAP-Rule:MF_01001}.
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DR EMBL; CP003938; AGB80228.1; -; Genomic_DNA.
DR AlphaFoldDB; L0M8K4; -.
DR STRING; 693444.D782_4358; -.
DR KEGG; ebf:D782_4358; -.
DR PATRIC; fig|693444.3.peg.4157; -.
DR eggNOG; COG1922; Bacteria.
DR HOGENOM; CLU_063203_3_2_6; -.
DR OrthoDB; 9808602at2; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000011002; Chromosome.
DR GO; GO:0047241; F:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd06533; Glyco_transf_WecG_TagA; 1.
DR HAMAP; MF_01001; WecG_RffM; 1.
DR InterPro; IPR023085; UDP-ManNAcA_Trfase_WecG.
DR InterPro; IPR004629; WecG_TagA_CpsF.
DR NCBIfam; TIGR00696; wecG_tagA_cpsF; 1.
DR PANTHER; PTHR34136; -; 1.
DR PANTHER; PTHR34136:SF1; UDP-N-ACETYL-D-MANNOSAMINURONIC ACID TRANSFERASE; 1.
DR Pfam; PF03808; Glyco_tran_WecG; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_01001};
KW Reference proteome {ECO:0000313|Proteomes:UP000011002};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01001}.
SQ SEQUENCE 246 AA; 28056 MW; A09D128897FF3D14 CRC64;
MTDSHTAPTY ELRGLKLVGW RNMQHALDFL YADGQLKSGT LVAINAEKML TAEDNAEVRT
LINAAEYKYA DGISVVRSVR KKYPQADVSR VAGADLWEAL MARAGREGTP VFLVGGKPEV
MAQTEAKLRQ QWNVNLVGTQ DGYFKPEQRQ ALFERIRDSG AKIVTVAMGS PKQEILMRDC
REIYPDALYM GVGGTYDVFT GHVKRAPKFW QNLGLEWLYR LLSQPSRITR QLRLLRYLRW
HYTNQL
//
