ID   L1KIJ7_9ACTN            Unreviewed;       757 AA.
AC   L1KIJ7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=STRIP9103_02540 {ECO:0000313|EMBL:EKX60280.1};
OS   Streptomyces ipomoeae 91-03.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX60280.1, ECO:0000313|Proteomes:UP000010411};
RN   [1] {ECO:0000313|EMBL:EKX60280.1, ECO:0000313|Proteomes:UP000010411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91-03 {ECO:0000313|EMBL:EKX60280.1,
RC   ECO:0000313|Proteomes:UP000010411};
RA   Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKX60280.1}.
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DR   EMBL; AEJC01000665; EKX60280.1; -; Genomic_DNA.
DR   RefSeq; WP_009342140.1; NZ_AEJC01000665.1.
DR   AlphaFoldDB; L1KIJ7; -.
DR   PATRIC; fig|698759.3.peg.8953; -.
DR   OrthoDB; 3196525at2; -.
DR   Proteomes; UP000010411; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 3.30.2310.20; RelE-like; 1.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF143011; RelE-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000010411}.
FT   DOMAIN          254..565
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          118..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..140
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         275..282
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   757 AA;  84672 MW;  69ACCC120051B0E5 CRC64;
     MNTSGVTLRL LDKADKEILK LPRTVKGAFF DFQHKFRSNP HTTGLKLQQL KGDSRLWSAR
     VNDEYRALLL RLADDDWLIV SVKHRKDVYN RLSYGVNQVT GGIEYVDLEV VEDSVLRRLP
     TPPAPAPTTT EAPTPAQPEP ARPLFADWSD QQLSDLGVAE PLLPVIRTLA TEDQLLGLVE
     YAPQLTGEVL LALFDGASYD DVLDQVTRPV AATEPVDPDD FEAAAQRPAT VVTTTDDALR
     EALESGDFGR WKVFLHPTQA KLVERRYNGP ARVGGGPGTG KTIVALHRVR HLVRQLPPGR
     DKPVLLTTYN KNLAADLRSR LLELGGEELL SRVEVSHVDQ LALRIVREAE PGNGKQAIDD
     SQAVREWRAL LDELGEDGWD PEFLHDEWTQ VILGQAVGTR TDYFRARRAG RGRNIGRAER
     AEIWQLAERF AQRLDRLGRQ TWDQVAERAA RLEMGREQRI QNIARQREEA GGLDNVHLQD
     GSGGWLRHRY RHIVVDEAQD LRPAHWKMLR AMAPRGADDL FLVGDTHQRI YKNQVTLGSL
     GINIRGRSSK LSLSYRTTRQ ILRSALGVLG ETKYDDLDGS EETLAGYRSV LSGGRPAGHA
     FPDWIAEREG VAMLIKEWDA DTDMTIPHEQ IAICVPTNQM AAEMAYTLKL HGIDSVEIRS
     DGPHGSTGVH IGTMFRFKGL EYQRMIISGV ADGLVPREAV NRLRDTDPVR YRHEIQRARS
     LLFVAATRAR DSVDVFWHGK PSPFLDGSWV AAGPAVN
//