ID L1KIQ9_9ACTN Unreviewed; 326 AA.
AC L1KIQ9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
DE AltName: Full=Galactowaldenase {ECO:0000256|ARBA:ARBA00033067};
DE AltName: Full=UDP-galactose 4-epimerase {ECO:0000256|ARBA:ARBA00031367};
GN Name=galE_5 {ECO:0000313|EMBL:EKX60706.1};
GN ORFNames=STRIP9103_08525 {ECO:0000313|EMBL:EKX60706.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX60706.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX60706.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX60706.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX60706.1}.
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DR EMBL; AEJC01000634; EKX60706.1; -; Genomic_DNA.
DR RefSeq; WP_009339276.1; NZ_AEJC01000634.1.
DR AlphaFoldDB; L1KIQ9; -.
DR PATRIC; fig|698759.3.peg.8578; -.
DR OrthoDB; 9801785at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Isomerase {ECO:0000313|EMBL:EKX60706.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411}.
FT DOMAIN 3..240
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 326 AA; 34556 MW; 9CA81882F8B9EDFF CRC64;
MTWLITGGAG YIGAHVARVM TDAGEEVVAL DDLSAGVRGR LPERIPLIQG SAQSPDLLKR
VLTDHAVTGI VHLAARKQVG ESVAEPTRYY QENVGGLATL LEAATGAGVE RFVFSSSAAV
YGNPDVDLIT EDTPCAPMSP YGETKLAGEW LVRAAGRAHG ISTVCLRYFN VAGAAEPALA
DTGVFNVIPM VFDRLSRDEA PRIFGDDYPT PDGTCVRDYI HVADLAEAHL AAARRLTAEG
TDGTAGELTV NIGRGEGVSV RELIALIGEV TGDSRPAIVE PRRPGDSPRA VASAALAERE
LGWTARRGVR EMVESAWAGW RLHHGL
//
