ID L1KJS0_9ACTN Unreviewed; 590 AA.
AC L1KJS0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Precorrin-3B C(17)-methyltransferase {ECO:0000313|EMBL:EKX61071.1};
DE EC=2.1.1.131 {ECO:0000313|EMBL:EKX61071.1};
GN Name=cobJ {ECO:0000313|EMBL:EKX61071.1};
GN ORFNames=STRIP9103_01959 {ECO:0000313|EMBL:EKX61071.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX61071.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX61071.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX61071.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX61071.1}.
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DR EMBL; AEJC01000621; EKX61071.1; -; Genomic_DNA.
DR RefSeq; WP_009338045.1; NZ_AEJC01000621.1.
DR AlphaFoldDB; L1KJS0; -.
DR PATRIC; fig|698759.3.peg.8246; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0030789; F:precorrin-3B C17-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EKX61071.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EKX61071.1}.
FT DOMAIN 36..116
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 202..323
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 331..536
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT REGION 568..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 60982 MW; 6BC45CDB5B5225FC CRC64;
MIGLISATAA GAVAAQRLAS AWPERTRVYE GPVRDAVRRA FGECEQLVCF LATGATVRVL
APLLADKATD PGVVCVDEGG RFAVSLIGGH GGGANELARE VGELLGAEPV ITTATDAVGV
PGLDTLGLPV EGDVAGVSRA VLDGEAVELD LEIGWPLPAL PSNVGHSASQ RSRAPRQAPV
IRVTDRVLEP AEGQVVLRPP SLVVGVGASK GAPVDEVLAL VEKALHDAGL SPKSLAEIAT
VDAKADEPGI VEAAERLGVP LVTHSAEELA AVEVPNPSDA PLAAVGTPSV AEAAALVRGG
ELLVAKRKSE RADGRPAMAT CAVVRRPARG RLAVVGLGPG ARDLLTPRAK AELQGASVLV
GLDQYVDQIR DLLRPGTRVL ESGLGAEEER ARTAVAQARK GYAVALIGSG DAGVYAMASP
ALAEASDDID VIGVPGVTAA LAAAAILGAP LGHDHVSISL SDLHTPWEVI ERRVRAAAEA
DIVVTFYNPR SRGRDWQLPK ALAILAEHRE PTTPVGVVRQ ASRPDESARV TTLAALDPAT
VDMMTVVTVG NTASRTIAGR MVTPRGYRWQ TDTQTEPRTK TRTKTQEAAG
//
