ID L1KY81_9ACTN Unreviewed; 2842 AA.
AC L1KY81;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative [acyl-carrier-protein] S-malonyltransferase {ECO:0000313|EMBL:EKX65283.1};
DE Flags: Fragment;
GN ORFNames=STRIP9103_00430 {ECO:0000313|EMBL:EKX65283.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX65283.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX65283.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX65283.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX65283.1}.
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DR EMBL; AEJC01000298; EKX65283.1; -; Genomic_DNA.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EKX65283.1}.
FT DOMAIN 856..931
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 948..1374
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1882..1957
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1979..2405
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1864..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2409..2429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKX65283.1"
FT NON_TER 2842
FT /evidence="ECO:0000313|EMBL:EKX65283.1"
SQ SEQUENCE 2842 AA; 297608 MW; 4DE7265F3953AA97 CRC64;
DHAEAVTGLE ALAQGEAAPG VITGTAAGDG VLAVLFTGQG SQRPGTGREL YERYPVFRDA
FDAVCVALDE QLTGHVPYPV AEVAFAEPGT DKAAWLDQTC YTQTGVFALE TALFRLVESF
GVTPDHLAGH SVGELTAAHV AGILTLPDAA KLVAARARLM QSLPAGGRMI ATTAPETDVL
PLLTDRVTIA AVNGPRSVVI SGDEDDVTVL AERLVAAGHQ VRGLTVSHAF HSPRMEPILA
EFTEIAATVA YHPARLPVIP NTTGRPAADG DLTTPEYWAR HIREAVRFAD TVTTLTDSGV
DVFLELGPSP HLTAAVEEFT DTTCVPALCH GQPEAQSVLA AVARLYTSGV PVDWADAFAA
TGARRVPLPT YPFQHTRYWL ADTAPGAGSA RTPSAGALYA VEWTELPVHV RAEEGAHAGA
GEEPYVVRVR TVEDVAAAAV DEAPAHLLFE ATGPADARDL VSRALEIVQA VLAEPRLDAT
RLVVVTRDDG QPESGAVRGL VRSAQSEHPG RLVLVRADTD ADTATGSLLL ATGEPEARLT
GGELAAPRLV RVHPEGEATG PDPDGTVLVT GGTGSLGGLV ARHLVREHGV RHLLLVSRRG
PEADGVEELR SELAELGAEA RVVACDVADR AALAALLGEI PAEHPLTAVV HTAGVIDDAV
VTGLTAEQID RVYRPKVDAA VHLDELTRDL DLRAFVLFSS AAGVFGNPGQ GAYASANAFL
DALAERRRSL GLPAVSLAWG HWSHGDGMAA HLSEADVRRN RRMGMAGLSA RAGLALFDAA
LRAEPAVLVA ARLDLTGLTP VTGLTGGTGP YADETPVPAL LRALVPAPAA GATVAAPAEG
GVAARLAALD EAGQDELLLD LVRGEAAAVL GHSNPEALVA ERAFKEAGFD SLMAVELRNR
LNARTGLRFS PTLLFDHPTP RALARHLRAE LLGATPEQTR RTRTAPVDEP IAIVGMSCRF
PGGANSAEEL WRLVADGTDA VTGFPTDRGW DLASLHHPDP DHPGTSYVVH GAFLDDAAGF
DADFFGISPH EALAMDPQQR LMLEASWEAL EHAGIDPTSL RGEPVGVFAG VNSQDYARSL
DQVPDHVEGY RITGISAGVV SGRVAYTLGL EGPAVTLDTA CSSSLVTMHL AAQALRSGEC
SMALSGGVMV MASPEPFVEF SRQRGLAPDG RCKAFAAAAD GTGWSEGVGV LLLERLSDAR
RNGHRVLAVL KGSAVNQDGA SNGLTAPNGP SQQRVIRQAL AAAGLAPTDV DAVEAHGTGT
TLGDPIEAQA IIATYGRDRP DDRPLWLGSV KSNIGHTQAA AGVAGVIKMV QAMRHGVLPR
TLHVDEPTGE VDWPAGAVEL LTEARPWPET GRPRRAGVSA FGVSGTNAHV ILEQAPPEHE
PEAPHEPVGD ATRPAMPPTA LPAVPWVISA RTEAGLRGQA AKLAAFAAAD DRGSAAVAHS
LLTTRAALEH RAVVVGEDRT RLVAGLAALA GGEPLTVGVV RGTVTGGKLA YLFNGQGSQR
PGMGRELHCR YPVFRDAFDA ACAELDRHLA GHVERPLREV VFSEPGTHEA ALLDETVYAQ
SGLFALETAL FRLYESWGVR PDYVTGHSLG ELSAAHAAGM LSLADAAALV AVRGRLMQAL
PRGGAMAAIG ATEEEVARAI AAHGDTCGGA VDISAVNGPT ALVISGAEDA VLAVAEDFRA
RGHQVKRLRV SHAFHSSRMD GMLDEFREAA AGVSFRPPSL PVVSSLSGRL ADPEELRSPD
YWAAQARGCV RFHDAVLALR DLGVRTHLEL GPGGVLGATA AEVHGEDPSV PALAKGEPEA
VTAVAALGHL HVRGVPVEWT ALFDGVAPER VDLPTYAFQH RRFWPEATHG RTIRTSTAVE
PVTDVRRPER NEPERNEPER DESVLALVLR ATAAVLGQND PSAVDSTRAF RDLGFDSLAA
VRLRNELMNT LGVELPATVA FDHPTPAALA TFLSPGGSPG GDHRQETPLA PVPAPAAPDE
PIAIVAAACR LPGDITSPEQ LWDLVASGTD AVTGFPVNRG WNLDELFHPD PDHPGSSYVR
EGGFLHDAPG FDAAFFGISP REALAMDPQQ RLLLETSWEA FERAGLDPTS LRGRPVGVFT
GIVHHDYVTR LREVPEGYEG YLITGAAGSV AAGRVSYLFG FEGPAVSVDT ACSSSLVSIH
LAAQSLRAGE CSMALAGGAT VMAGPDAFIE FSRQRGLAMD GRCKAFAAAA DGTGWSEGVG
VVLLERLSDA RRNGHRVLAV LRGSAVNQDG ASNGLTAPNG PSQQRVIRQA LANAGLTASD
VDVVEAHGTG TTLGDPIEAQ ALLATYGQGR PEDRPLWLGS LKSNIGHAQA AAGVAGVIKM
VMALQEGVLP QTLHVDEPTP QVDWSAGAVS LLTEARDWPE TGRPRRAAVS SFGMSGTNAH
LILEQAPETG GVEGPEASDG HGGAELRGDT PEPGVVPLPL SARGQEALQE QARQLLAHLG
ELGERGPRLV DVGHSLVATR ATHSHRAVVV ATGAEQARAA LAALARGEDH PDVVTGTAGA
GGRTVFVFPG QGSQWVGMGA GLLDASPVFA DHIRACAEVL DPLTGWSLLD VVRGGDLGRV
DVVQPATFAV MTGLAALWRD HGVVPDAVVG HSQGEIAAAY VAGALSLADA ARVVALRSQA
IAERLAGRGG MVHVTLGREG TEELLKGWPD RLEVAAVNGP ASTVVAGDVD AVEEFLEHCA
SERVQARRIP VDYASHTHHV EGIREQLLMV LDGIEPQPAR IPLFSTVDGT WLDTTVMTAE
YWYRNLRQTV GFGTAVESLY AEGYRVFVEA SPHPVLTHSV QDTIDGALAT GTLRRGHGTL
ADFTTALARL HTNGVPVTWH HP
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