ID L2E922_9BURK Unreviewed; 967 AA.
AC L2E922;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=D769_28452 {ECO:0000313|EMBL:EKZ95815.1};
OS Cupriavidus sp. HMR-1.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1249621 {ECO:0000313|EMBL:EKZ95815.1, ECO:0000313|Proteomes:UP000010442};
RN [1] {ECO:0000313|EMBL:EKZ95815.1, ECO:0000313|Proteomes:UP000010442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMR-1 {ECO:0000313|EMBL:EKZ95815.1,
RC ECO:0000313|Proteomes:UP000010442};
RX PubMed=23409271;
RA Li L.G., Cai L., Zhang T.;
RT "Genome of Cupriavidus sp. HMR-1, a Heavy Metal-Resistant Bacterium.";
RL Genome Announc. 1:E00202-E00212(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKZ95815.1}.
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DR EMBL; ANKP01000255; EKZ95815.1; -; Genomic_DNA.
DR AlphaFoldDB; L2E922; -.
DR PATRIC; fig|1249621.3.peg.5637; -.
DR Proteomes; UP000010442; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:EKZ95815.1};
KW Ion transport {ECO:0000313|EMBL:EKZ95815.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKZ95815.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:EKZ95815.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 483..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 736..950
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 106048 MW; 7C1423AC36E55255 CRC64;
MYAWQSPAWH NHRHQPPLPM TDPDARPDPD ALLQRMQAER ARAARGKLRV YFGASAGVGK
TFAMLGAARA LREQGVDVVV GVVETHGRAE TEALLDGLER LPLREVPYRD RVLAEFDLDG
ALARRPALIL VDELAHSNAA GSRHPKRWQD IQELQATGID VWTTVNVQHL DSLNQAVGGI
TGVRVWETVP DAVFDGADEV VLVDLPADEL LRRLREGKVY LPDQARHAAR NFFRKGNLIA
LRELALRRTA DRVDDDVRAY RHAESIDLVW RTREALVACI GTGDDAEQVV RSAQRLAGQL
DCDWHVVTIA TPQLMPPSNE VRARMRAAMQ LAEELGARTE TLAGNDMVKA VAGYVRRHNL
TKVLLGRAPA DWYARGNWID KGRALLARAL SPMLGVGNRL FGRQMFADAL AAGCPEIDVI
RVAADSTRAD LRPRAQEGLS TAAHDAEAEA ELARVRRLNY GWAVVWCMAA TFLSTLTRPW
FDLVNIAMLF LVAVVGVALR HGRGPAALAS VISVAAFDFF FVPPRMSFAV SDVQYLLTFF
VLLAVGLVIG QLTAGLREQA QVSVRRETDA RTLYELAREL SAALTAQQIV EIGGRFLRAA
FDADGTFFLV AENGRLMPMA GGEKTPEPRT GKGDAIDKVL AQWVFDHGQP AGTGTHTLPG
STVLYLPLKA PMQTRGVLAV EPRAWRALAD PALRRQADVF ATLIAIAIER IHYVDVAQRA
LVSIESERLR SSLLAAVSHD LRTPLTGLIG MAETLQRAET PLPASVAETV EAMRVQAQRM
RTMVVNLLDM ARLQHHDLAL KRGWQSLEEL IGAALASMRD VLGRHHVEVM NLAELPLVEC
DDVLMERVLC NLLENAAKYT PAGTAIRIRG AVVGDEVQLS VEDEGPGVQS GQERYIFEKF
TRGERESATS GVGLGLAVCE AIMQAHGGRI WVEAAHPRGS RFTLALPRGN PPAIEPESLD
EPIPDHH
//
