ID L5JMQ2_PTEAL Unreviewed; 505 AA.
AC L5JMQ2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN ORFNames=PAL_GLEAN10018582 {ECO:0000313|EMBL:ELK00625.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00625.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; KB031156; ELK00625.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JMQ2; -.
DR eggNOG; ENOG502QTVF; Eukaryota.
DR InParanoid; L5JMQ2; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 101..278
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 358..430
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 278..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..147
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 236..263
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 437..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 58819 MW; F18ECEA25D1E2F6E CRC64;
MAPEEEEKLQ EILIHACPKS SNNLGNWKTV LDHNNESELH QRQDNIMDSE LMHSIVGSYL
KPPESVFFPS FTENDESSQN HHSVNFEVTS PKMLHSPNSQ ALILALKTLQ EKIHRLELER
TQAEDNLNIL SREAAQYKKA LEIETNERNL VHQELIKQKK DISIQLSSAQ SRCTLLEKQL
EYTKRMVLNV EREKNIILEQ QAQLQREKEQ DHMKLQAKLE KLDVLEKECF KLTATQKTAE
DKIKHLEEKL KEEEHHRKLF QDKASELQTG LEINRILMSS VSNPKRSKEK KKSSKKTKCL
KREPPQQIYS KFESPPVAAE KMVQHYGPHI LQKPAEVIER RCLYKPRTTS QCKAVAPDSK
KSISICDNLS ELLVAMQDEL DQMSIEHQEL LNQMKEAESH SVCEDLECEL EHLVKKMKIK
EEQISKLLKH QDSVRKLQQK VQNPKMSEAS GIQREDNNPK GSKNIKNSPR KCLLTNSLQK
NSNFHPIRVH NLQMKLRRDD IMWEQ
//
