ID L5JPN0_PTEAL Unreviewed; 1096 AA.
AC L5JPN0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Laminin subunit alpha-2 {ECO:0000313|EMBL:ELK00721.1};
GN ORFNames=PAL_GLEAN10018700 {ECO:0000313|EMBL:ELK00721.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK00721.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; KB031156; ELK00721.1; -; Genomic_DNA.
DR AlphaFoldDB; L5JPN0; -.
DR STRING; 9402.L5JPN0; -.
DR InParanoid; L5JPN0; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 7.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF291; LAMININ SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 8.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00180; EGF_Lam; 8.
DR SMART; SM00281; LamB; 2.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 5.
DR PROSITE; PS51115; LAMININ_IVA; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}.
FT DOMAIN 1..193
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 321..375
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 376..424
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 445..631
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 632..676
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 706..758
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 759..821
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 836..1035
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DISULFID 321..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 351..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 395..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 646..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 742..756
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 759..771
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 792..801
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1096 AA; 121492 MW; 5C5AE1F8B6925E53 CRC64;
MGKRTILLDS PLHSSMFFER GKLWCSLADY YIRSGHFEKV FQIAYVIVKA ANSPRPGNWI
LERSLDDVEY KPWQYHAVTD TECLALYNIY PRTGPPSYAK DDEVICTSFY SKIHPLENGE
IHISLINGRP SADDPSPELL EFTSARYIRL RFQRIRTLNA DLMMFAHKDP REIDPIVTRR
YYYSVKDISV GGMCICYGHA RACPLDPVTN KSRCECEHNT CGDSCDQCCP GFHQKPWRAG
TFLTRTECEA CNCHGKAEEC YYDENVARRN LSLNIHGKYI GGGVCINCTQ NTAGINCETC
ADGFFRPKGV SPRYSRPCQP CHCNSIGSLN KVCVKDEKHA RRGLAPGSCH CKPGFSGVSC
DRCARGYTGY PDCNPCNCSG EGSTNEDPCV GPCNCKENVE GGDCSRCKSG FFNLQEDNHK
GCDECFCSGV SSRCQSSYWT YGSILDMSGW YLTDISGRIR VAPQQENLDS PQQISISSVE
ARRALPQGYY WSAPASYLGN KLTAAGGQLT FTVSYDLEEE EEEDTEGILQ LMIILEGNDL
RISTAQDEVY LQPSEEHINI LSLKEELFTV HGTNIPVSRK EFMTVLVDLK RVLIQITYSL
GVDAIFRLSS VGLESAVPYP TDGSFATAVE VCQCPPGYTG SSCENCRDHT GGPYCNKCLP
GFYGDPTKGT SEDCQPCACP LNIASNKCAE GYFGQPSVPG GSCQPCQCND NLDFSIPGSC
DSLSGSCLIC KPGTTGRYCE LCADGYFGDA VDAKNCQPCR CNANGSLSEI CHARTGQCEC
RPNVQGPRCD ECKVNVEGVH CDRCRPGKFG LDAKNPLGCS SCYCFGAATQ CSEAKGLIRT
WVTLKPEQTI LPLVDEALRH TTTKGIIFQD PEIVADMDLV REDLHLEPFY WKLPEQYEGK
KLMAYGGKLK YAIYFEAREE TGFTTYNPQV IIRGGTPTHA RIIIRHMAAP LIGQLTRHEI
EMTEREWKYY GDDPRVSRTV TREDFLDILY DIHYILIKAT YGNVMRQSRI SEISMEVAEK
GRITAVTPPA HLIERCDCPP GYSGLSCETC MPGFYRLRSE PGGRTPGPTL GTCVPCQCNG
HSSLCDPETS ICQVFT
//
