ID L5K082_PTEAL Unreviewed; 583 AA.
AC L5K082;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Neuralized-like protein 1A {ECO:0000313|EMBL:ELK04985.1};
GN ORFNames=PAL_GLEAN10014228 {ECO:0000313|EMBL:ELK04985.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04985.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031059; ELK04985.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K082; -.
DR STRING; 9402.L5K082; -.
DR eggNOG; KOG4172; Eukaryota.
DR eggNOG; KOG4625; Eukaryota.
DR InParanoid; L5K082; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16785; mRING-HC-C3HC5_NEU1A; 1.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12429:SF13; E3 UBIQUITIN-PROTEIN LIGASE NEURL1; 1.
DR PANTHER; PTHR12429; NEURALIZED; 1.
DR Pfam; PF07177; Neuralized; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00588; NEUZ; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51065; NHR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 71..227
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 302..457
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 530..570
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 500..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 63291 MW; BB9E2A9FAC96CA4B CRC64;
MREQEEGSWF PPISGDIGRH ICMHIWLLEM SEIGMSQNSI GGPFPVTSHR CHHKQKHCPP
VLPGGVLPAT PLLFHPHTKG SQILMDLSHK AVKRQASFCN AITFSNRPVL IYEQVRLKIT
KKQCCWSGAL RLGFTSKDPS RIHPDSLPKY ACPDLVSQSG FWAKALPEEF ANEGNIIAFW
VDKKGRVFYR INDSAAMLFF NGVRTADPLW ALVDVYGLTR GVQLLDSELV LPDCLRPRSF
TALRRPSLRR EADDARLSVS LCDLNVPAAD SDEATLAVGC PIPQNSLNSQ HSRALPAQLD
GDLRFHALRA GAHVRILDEQ TVARLEHGRD ERALVFTSRP VHVAETIFVK VTRSGGARPG
ALSFGVTTCD PGTLRPADLP FSPEALVDRK EFWAVCRVPG PLHSGDILGL VVNADGELHL
SHNGAAAGMQ LCVDASQPLW MLFGLHGAVT QIRILGSTIL AERGIPSLPC SPASTPTSPS
ALGSRLSEPL LSTCSSGPLG SSAGGTAPNS PVSLPESPVT PGPGQWSDEC TICYEHAVDT
VIYTCGHMCL CYACGLRLKK ALHACCPICR RPIKDIIKTY RSS
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