ID L5K083_PTEAL Unreviewed; 3363 AA.
AC L5K083;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:ELK05104.1};
GN ORFNames=PAL_GLEAN10008175 {ECO:0000313|EMBL:ELK05104.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK05104.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB031047; ELK05104.1; -; Genomic_DNA.
DR STRING; 9402.L5K083; -.
DR eggNOG; KOG1786; Eukaryota.
DR InParanoid; L5K083; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2757..2863
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2868..3176
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3174..3208
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 147..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1903..1994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2034..2064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1428..1455
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 158..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1003
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1946..1974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2063
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3363 AA; 375742 MW; 54D71FE6148C0A81 CRC64;
MSTDSNSLAR EFLTDVNRLC NAMVQRAEAR EEEEETHMAT LGQYLVHGRG YLLLTKLNST
IDQALTCREE LLTLLLSLLP LVWKIPVQEE KAADFNLPFS PGIILTKEKN SNSQRSAQEK
LYLEGSAPSG QVPAKFSVFR KSRRQRKITH RYSVRDARKT QLSTSESEAN SDDRSVAANK
PRRPHQLPRS GTQSSKEDGL AAQPARPSAK EQSPPGTMAS ESFQIMPGQA ANADVLSEPA
ALSIISHMNN TPFDLCHVLL SLLEKVCKFD IALNHNSALA ASVVPTLTEF LAGFGDCRHL
SDNLESQMVA AGWTEEPVAL IQRMLFRTAL HLMSVDISTA ETMPERLRKN LTELLRAALK
IRTCPEKQPD PFAPRQKGTL QEVRESFVFS KCRHRALLLP ELLEGVLQIL VSCLQSAASN
PSFFGQAVDL VQDFIQHHGF NLFETAVLQM EWLILRDSAP AEASEHLKAL INGVLKIMSA
VKRAKAEQLH HSVCPRKRHR RCEFAHFLHH HSDLSGLLAS AFRNQVSGNP FAESADGDGD
GDARPPXXXL PALKSFQQPI LNILNKLILD QLGGAEVSHK IKKAACNICT ADSDQGAKLG
EALALRAGSR DAQPRXXXXX XXXXXXXXXX XXXXSEDLLW KWDALEVYQS FVFEEDGLLS
APVAHHICSL LLKGNVAVQW KLYHCVLNPV LRRAVELAHH CRQLSVPPAQ THVCSHRNQC
LPWEVLQIYL KTLPTLLKSR IIRDLFLSCN GVSQIIELNC LDGIRSHSLK AFETLIISLG
EQQEDSSISG TDGVDTEQES SSLNAGASFH NQQAYPESPP SLSKFYTSLR EAYPKKRKSA
NQDVHIDTIN LFLCVAFLCV SKEAESDGES ANDSGDTSGY DSTASEPLLR VLPRVSLESL
VLPSREHMQQ AADIWAMCRW IYTLSPVFQK QFCRLGGFRA CYKLIFMIIQ ELFRSHKQEQ
GQKGDMNVYE HQDLTRTSRS EIPVKEDLSP PPGESPPTPS GPGSPEQSAD TSGDLEAQQI
SSINLKQVSA TAAAPEETEV PTSRESEVSL PSEVSLQSIR LLEALLAICL HSSRARQQKT
ELEGPDQNLS VENILFEMRD HLSRSKVIET ELAKPFFDAL LRVAQGSHSA EFERSDAVAE
KGHQSEELSS QPGDFSEEAE DSQCCSFKLW VEEEGYEADS ESNPEDSDTW DDGIDVKLEA
EGFVASSSPN GLLENLSQGE LIYPEICMLE LSLLSTGKAN LDVLTHVFES FLKIVRQKEK
NIFLLIQQGT VKSLLGGFLS ILTQADSDFQ ACQRVLVDLL VSLMKLTLLL RIFLEKSPCT
EILLLGILKI VESDIAMSPL QYLTFPVMHT PHSSSGVSSQ RCPGSLSSKA MGLLRRAHVS
RSKKEADGDS FPQQLFSPWQ VAPVHLPLPG QNCWPHLSEG FSVSLWFNVE CAQEAESATE
KRKKMKKRNR SLILRGGSVD GTENNRPEGA EYMSPSERLM EEGCVHMMSL GSKALMIQVW
ADPHAGTLIF RMCVDSNDDA KAVLLAQAES QENVFLPSKW QHLVLTYLQQ PQGKKNVHGR
MSMWVSGQRK PEVTLDFVLP RKTSLSSDSN KTFCMIGHCV SSQEEFLQLA GKWDLGNLLL
FNGAKIGSQE AFYLYACGPN HTSIMPCKYG KPVIDYSKYI NKEILQCEQI RELFMTKKDV
DVGLLIESLS VVYTTYCPAQ YTIYEPVIRL KGQAKTQLSQ RPFSSKEVQS ILLEPHHLKN
LRPTQCQTIQ GILHEIGGTG IFVFLFARVV ELSSCEETQA LALRIILSLV KYNQQRIHEL
ENCNGLSMIH QVLIKQKCTV GFHVLKTLLE GCCGEDILHI SENGEFKLDV ESNAIIHDVK
LLEALLLDWK IWRKAEAHGK VFQEKVESIM YLRHSSSGGK AVPSPGLVVI SPSDFTASPP
EGNSSSGITP PRTTADLRRS RSLPALPTSP LAQPQKLTGS SGGGIDSLQS TADHRVDSQP
EKWGPLGTSE TLKKGPEDAF VSSCESAKTV CETEAVLSRQ VSVNGVPKGA LEYPAVKVDP
KEPGAEPRSD DDSPGDESCP RRPDYLKGLA SFQRSHSMIA SLGLAFPSQN GSAAIGRWPS
LVDRNAEVWE NVTFSLGYEP NYARTANAHS VMEDCLVPIC CGLYELLSGV LLILPDAMLE
DVMDKLIQAD VLLVLVNHPS PAIQQGVIKL LDAYFNRASK EQKDKFLKNR GFSLLANQLY
LHRGTQELLE CFVEMFFGRH VGLDEEFDLE DVKNMGLFQK WSVIPILGLI ETSLYDNALL
HNALFLLLQI LNSCSKVADM LLDNGLLYVL CNTVAALNGL EKNIPLNEYK LLACDIQQLF
IAVTIHACSS SGSQYFRVIE DLIVLLGYLQ NSKNKRTQNM AVALQLRVLQ AAMEFIRTTA
NHDCEHPADS LSLPSAPHHA VFQKRKSIAG PRKFPLAQTD SLLMKMRSVA SDELHVMMQR
RLSQENPVQA SEAELAQRLQ RLTVLAVNRI IYQDFNPEIV DILSTPEYAA QSKTSVSQTE
TSEENIHREQ PSIFNPFQKE ILTYLVEGFK VSIASGKGSG SKQQWTKILA SCKDTFRMQL
GRLLVHVVSP AHPSQQRKQI FEIVREPSYQ EILRDCLTPS LQRLDSKSKD ISKIAADITQ
AVSLSQGIER KKVIQHIRGM YKVDLSASRH WQELIQQLTH DRAVWYDPVY YPTSWQLDPT
EGPNRERRRL QRCYLTIPNK YLLRERQKSE DLVRPPLSYL FEDKTHSSFS STVKDKAASE
SIRVNRRCIS VAPSRETAGE LLLGKCGMYF VEDNASDAVE SSSLQGELEP ASFSWTYEEI
KEVHKRWWQL RDNAVEIFLT NGRTLLLAFD NTKVRDDVYH SILTNNLPNL LEYGNITALT
NLWYTGQITN FEYLTHLNKH AGRSFNDLMQ YPVFPFILAD YVSETLDLSD PAVYRNLSKP
IAVQYKEKED RYVDTYKYLE EEYRKGARED DPLPPVQPYH YGSHYSNSGT VLHFLVRMPP
FTRMFLAYQD QSFDIPDRTF HSTNTTWRLS SFESMTDVKE LIPEFFYLPE FLVNREGFDF
GVRQNGERVN HVNLPPWARN DPRLFILIHR QALESEHVSQ NICQWIDLVF GYKQKGKASV
QAINVFHPAV TSCAWVPDSC QLFTGSKCGV ITAHTNRLTS STPSEIEMES QVHLYGHTAE
ITSLFVCKPY SIMISVSRDG TCIIWDLNRL CYVQSLAGHK SPVTAVSASE TTGDVATVCD
SAGGGSDLRL WTVNGDLVGH VHCREIVCSV AFSNQPEGVS INVIAGGLEN GIVRLWSTWD
LKPVREIIFP KSNKPIVSLT FSCDGHHLYT ANSEGTVTAW CRKDQQRLKQ PMFYSFLSSY
AAG
//
