ID L5K2D0_PTEAL Unreviewed; 240 AA.
AC L5K2D0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN ORFNames=PAL_GLEAN10025923 {ECO:0000313|EMBL:ELK04663.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK04663.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361132};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU361132}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR EMBL; KB031068; ELK04663.1; -; Genomic_DNA.
DR AlphaFoldDB; L5K2D0; -.
DR STRING; 9402.L5K2D0; -.
DR InParanoid; L5K2D0; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR PANTHER; PTHR10037:SF14; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF47473; EF-hand; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:ELK04663.1};
KW Ion transport {ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Sodium {ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132}; Transport {ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 50..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 1..82
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 240 AA; 27436 MW; EE35240785453647 CRC64;
MLCLFQVTIF AGWDGMLNAV FNSKWSDCDP DKINPGTQVR GDCGNPFVGI IYFVSYILIS
WLIIVNMYIV VVMELLNIAS KKQTKALSED DFRKFFQIWQ RFDPDRTQYI DSSKLSDFAA
ALDPPLFMAK PNKGQLVAMD LPMAVGDRIH CFDILLAFSK RVMGKDTKIE KVLSEMESGF
MLANPFKITY EPITTTLKRK QEAVSATIIQ RAYKSYRLRQ NDKNTSDIHM IDDDRDGQAI
//
