ID L5K755_PTEAL Unreviewed; 918 AA.
AC L5K755;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sarcosine dehydrogenase, mitochondrial {ECO:0000313|EMBL:ELK07340.1};
GN ORFNames=PAL_GLEAN10012627 {ECO:0000313|EMBL:ELK07340.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK07340.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; KB030979; ELK07340.1; -; Genomic_DNA.
DR RefSeq; XP_006918158.1; XM_006918096.2.
DR AlphaFoldDB; L5K755; -.
DR STRING; 9402.L5K755; -.
DR GeneID; 102882489; -.
DR KEGG; pale:102882489; -.
DR CTD; 1757; -.
DR eggNOG; KOG2844; Eukaryota.
DR InParanoid; L5K755; -.
DR OrthoDB; 1815533at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF200; SARCOSINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 68..427
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 430..485
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 488..797
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 823..908
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 918 AA; 100365 MW; BBCD3BF6E627A699 CRC64;
MASLSRALRV AATRPPRSLA RCPGLCPLSS GARPTAEKNV PYQRTLKEER GPSAVAQGPS
RPLPSTADVV VIGGGSLGCQ TLYHLAKLGV SGALLLERGR LTSGTTWHTA GLLWQLRPSD
VEVELLAHTR RVVSHDLPEE TGLHTGWVPN GGLFIASSRQ RLLEYQRLMS LGKAYGVESH
VLSPAETKTL YPLMNVDDLY GTLYVPGDGT IDPAGTCSAL ARAATARAAQ IVENCPVTGI
RVRTDDFGVR RVAAVETEHG SIQTPCVVNC AGVWAGAVGR MAGVKVPLVA MHHAYVVTER
IEGIQNMPNV RDHDASIYLR LQGDALSVGG YEANPIFWEE VSDKFAFGLF DLDWEVFGQH
IEGAINRVPV LEKTGVKSTV CGPESFTPDH KPLMGEAPEL RGFFLGCGFN SAGMMLGGGC
GQELAHWIVH GRPEKDMYSY DIRRFHCSLT GHRRWIRERS HESYAKNYSI VFPHDEPLAG
RSMRTGPLHE ELLAQGCVFQ ERHGWERPGW FTPEGTAPVL PYDYYGAYGN RAHQDHAYGK
LLADEHTFDF PPHHDVIKQE CLACRGAAAV FDMSYFGKFY LVGLDARKAA DWLFSADVSR
PPGSTVYTCM LNHRGGTESD LTVSRLAPSP QASPLTPAFE GDGYYLAVGG ATAQHNSSYI
LAVLQDRRFR CQLIDSSEAL GLISIQGPAS RAILQEVLDA DLSNEAFPFS THKLVTAAGH
LVRAMRLSFV GELGWELHIP RLSCVPVYQA VMAAGAKHGL VPAGYRAIDN LSIEKGYRHW
HADLRPDDSP LEAGLAFTCK LKSATPFLGR EALEKQRAQG LRRRLVCLTV DEKVPVFGLE
AIWRDGRVVG HTRRAGFGFA IDKPIAYGYV RDPSGGLVSP DFVKSGDYAL ERMGVTYPAQ
AHLKSPFDPD NKRVKGIY
//
