ID L5KDT3_PTEAL Unreviewed; 835 AA.
AC L5KDT3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Rho GTPase-activating protein 4 {ECO:0000313|EMBL:ELK09730.1};
GN ORFNames=PAL_GLEAN10001412 {ECO:0000313|EMBL:ELK09730.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09730.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB030794; ELK09730.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KDT3; -.
DR STRING; 9402.L5KDT3; -.
DR eggNOG; KOG3565; Eukaryota.
DR InParanoid; L5KDT3; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..173
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 424..612
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 663..724
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 323..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..835
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 92361 MW; 33F5C284E8E8CD60 CRC64;
MRWQLSEQLR CLELQGELRR ELLQELAEFM RRRAEVELEY SRGLDKLAER FSGRGGRLGG
SSREHQSFRK EPSLLSPLHC WAALLQQTRQ QSRDSAALSE VLGGPLAQRL SHIAEDVGRI
VKKSKDLEQQ LQEELLEVVS ELQTRQAKFM EHKLKCTKAR NDYLLSLASV NAAVSNYYLH
DVLDLMDCCD TGFHLALGQV LRSYTAAESR TQASQMQGLG SLEEAVEALD PSGDRAKVLE
VHAVAFCPPL RFDYQPHEGD EVAEIRVEVE LRDEILPRAQ NIQSRLDRQT IETEEVNKTL
KATLQALLEV VALEDGDVLD SFQASPSTES LKSTSSDPGA RQAGRRRGQQ QETETFYIMK
LQEYLSGRSI LAKLQAKHEK LQEAIQRGDK EEREVSWTQY TQRKFQKSRQ PRPTSQYNQK
LFGGDMEKFI QSSGQPVPLV VESCIRFINL NGLQHEGIFR VSGAQPRISE IRDAFERGED
PLVEGCTAHD LDSVAGVLKL YFRSLEPPLF SPNLFGELLA SAELEAMEDR VELVSRLLAL
LPGPVLVVLR YLFTFLNHLA QYSDENMMDP YNLAVCFGPT LLPVPAGQDP VALQGRVNQL
VQTLILQPAR VFPLLTLLPG PVYEKCMAPP SASCLGDTQP EGLAGENEPE LEAGTPTQED
VPEGVVEAVA CFAYTGRTAQ ELTFQRGDVL RLHERASGDW WRGECVGTGA RGLIPHKYIT
LPGGAEKHLS QGSPAAGDLL SSPEGLLESV HRPEPCTPPG GPSGHRRHCL VPTSPERHVE
VDKAVAQTMD SVFKELLGKT AARQGLGPAA TNSPSSGARS PKPPGCSRLG KNKAS
//