ID L5KDZ6_PTEAL Unreviewed; 1003 AA.
AC L5KDZ6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Arylsulfatase E {ECO:0000313|EMBL:ELK09001.1};
DE Flags: Fragment;
GN ORFNames=PAL_GLEAN10002345 {ECO:0000313|EMBL:ELK09001.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09001.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; KB030851; ELK09001.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KDZ6; -.
DR STRING; 9402.L5KDZ6; -.
DR InParanoid; L5KDZ6; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR42693:SF12; ARYLSULFATASE D; 1.
DR PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR Pfam; PF00884; Sulfatase; 4.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 2.
DR PROSITE; PS00523; SULFATASE_1; 2.
DR PROSITE; PS00149; SULFATASE_2; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1003
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969136"
FT TRANSMEM 191..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..323
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 324..370
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 470..738
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 786..877
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELK09001.1"
SQ SEQUENCE 1003 AA; 110113 MW; F59A58C932F1E139 CRC64;
SFRSWLAVTL GVILGWQPSA GSDLSGSRPN IVLMLADDLG IGDIGCYGNG TLRQTPNIDR
LAAEGVRLTQ HIAAASVCTP SRAAFLTGRY PVRSGMVSSD GHRVLQWAAV SGGLPTNETT
FAKILKDHGY ATGLIGKWHL GLSCEHRDDH CHHPLRHGFD HFYGLPLSMM GDCVPGGLSE
KRAGLQRRLE FYALMAALAA LTLAAGAASH LLPGSWVLAV GAALAAALLS AASYFLGALI
VHADCFLMRN HEVTQQPMHF PRTTALVLQE ASAFIRRNRE GPFLLVLSFL HVHTPLLSTE
KFLGRSHHGP YGDCVEEMDW MVGSKGMGGW EGGIRVPGIV RWPGVLPAGR VIHEPTSLMD
IFPTVVELAG GQVPQDRVID GRGLLPLLLG TVPHSDHEFL LHYCETSLHA ARWHQRHKSL
LPATLASSRF QTLQLTGLGV GFAHLGFRQT PSGDLEQPSP QPGLRLHTAW TPHIDWLAEE
GVRLTQHLAA APVCTPSRAA FLTGRHAFRS GMDTSGRTRV LPWNACSGGL PENETTFARI
LQQRGYSTGL IGKWHQGVNC HSRTDHCHHP LRHGFDYFYG MPLTLINDCQ PGRPGQVSGV
VMPTLWHYTR LMALGVLTLG PGRTCGLVPV PRRAVAAAAG LVVLFFASWY ASFGFVRRWN
CILMRNGDVV EQPMDLERTA GRLLEEAVAY IERNQHRPFL LFVSLLHVHL PLVTARRFRG
KSQHGLYGDH VEEMDWIVVL RMSSWFAIST FPAVDVRGPV LDDAIAGFAD GSAVPSAGRL
CAIAREILRA IEENGLRNRT LVYFTSDHGG CFESTDSEGQ LGGWNGVYRG SKGMGGWEGG
IRVPGILRWP GVLSAGRVID EPTSLMDVFP TVVELAGGQV PQDRVIDGRS LLPLLQGATE
RSAHEFLFHY CGMYLHAARW HDKDREYSPS PRRCGGLCPA RFSRETDRED VRVGGRMAEK
NDALCSIGWW LVLAMFTGDG VCRLRPVQSC NRLYYRPRMH MKP
//
