ID L5KEL5_PTEAL Unreviewed; 481 AA.
AC L5KEL5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=tRNA pseudouridine synthase 3 {ECO:0000313|EMBL:ELK09777.1};
GN ORFNames=PAL_GLEAN10007637 {ECO:0000313|EMBL:ELK09777.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK09777.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; KB030791; ELK09777.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KEL5; -.
DR STRING; 9402.L5KEL5; -.
DR eggNOG; KOG2554; Eukaryota.
DR InParanoid; L5KEL5; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02569; PseudoU_synth_ScPus3; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR041707; Pus3-like.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR NCBIfam; TIGR00071; hisT_truA; 1.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 211..329
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 429..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..38
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 459..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 54159 MW; 5B386239AA055C35 CRC64;
MAENDIDRIQ TEKLLKRVQE LEQEVQRLKN KQANTKDSNV RENSSGVGKA KRAFDFSAHG
RRHVALKIAY LGWGYQGFAS QENTNNTIEE KLFEALTKTR LIESRQTSNY HRCGRTDKGV
SAFGQVISLD LRSHFPKGRD SEDFNLTDEV NDAAKEIRYT HILNRVLPPD IRVLAWASVE
PSFSARFSCL ERTYRYFFPR ADLDIVTMNC AAQKYVGTHD FRNLCKMDVA NGVINFHRTI
LSAQVQLVGQ GLAEERWQEP FQICQFEVTG QAFLYHQVRC MMAILFLIGQ GMEKPEIIDE
LLNVEKNPQK PQYSMAVEFP LVLYDCKFEN IKWIYDREVH EFNVTHLQQQ WANQAVKTHI
LYSMLQGLDS VAVPCGTEER PASGTTWPAC GCRLSATIAA SGEAGSLAAP APPDPFTALS
RSPCDLGGSS WRVTSMRPEE TPNPGHGPVG AQDCAPGNRY PDSETNSTYS APTSLQHRDG
R
//
