ID L5KHZ2_PTEAL Unreviewed; 473 AA.
AC L5KHZ2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
GN ORFNames=PAL_GLEAN10011846 {ECO:0000313|EMBL:ELK10917.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK10917.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
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DR EMBL; KB030715; ELK10917.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KHZ2; -.
DR STRING; 9402.L5KHZ2; -.
DR eggNOG; KOG3880; Eukaryota.
DR InParanoid; L5KHZ2; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 133..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 406..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 441..463
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT REGION 273..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 51572 MW; 1DF0DB235EEC3219 CRC64;
MSQTLIRPIA ANSELLLTLD SSGDLNLIPW EAVLAHGGAF RILRVSIPHQ REETAPESRL
PLPDSQGAHW KNAMGFWLLG LCNNFSYVVM LSAAHDILSH QRASGNQSHV DPEPMPIPHN
NSSRFDCNSV STAAVLLADI LPTLVIKLLA PLGLHLLPYS PRVLVSGVCA AGSFILVAFS
HSVGTSLCGV VLASISSGLG EVTFLSLTSF YPRAVISWWS SGTGGAGLLG ALSYLGLTQA
GLSPQHTLLS MLGIPALLLA SYFFLLTFPE PQDPGGEEEA ERAARQPLIS NEAPESKPDT
SSNLSLQERW TVFKGLLCHI IPLVLVYFAE YFINQGLFEL LFFRNSSLSH AQQYRWYQML
YQAGVFASRS SLRCCHIRFT WALALLQCLN LALLLADVWL SFLPSIYLVF LIILFEGLLG
GAAYVNTFYN IAQETTDEHR EFAMAAACIS DTLGISLSGI LALPLHNFLC HLS
//
