ID L5KKX9_PTEAL Unreviewed; 819 AA.
AC L5KKX9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide {ECO:0000313|EMBL:ELK11977.1};
GN ORFNames=PAL_GLEAN10015653 {ECO:0000313|EMBL:ELK11977.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK11977.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KB030666; ELK11977.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KKX9; -.
DR STRING; 9402.L5KKX9; -.
DR eggNOG; KOG0905; Eukaryota.
DR InParanoid; L5KKX9; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF29; PHOSPHATIDYLINOSITOL 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ELK11977.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 291..494
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 527..818
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 702..819
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 819 AA; 93190 MW; BE4A3E5CABF2903D CRC64;
MAYCWKTDLN PGESDEELHK HQELYSENQP LFPSQVSLGF DQVVDEISNK IPLYQSEIEE
NAIFVPSAPN RNSKKHSLDA TQQISLNEFT SKTSELSHHQ VRKTPVIGFR RSVLTNAQNM
NKESSCGNPT GKCHGADDYR FNILASSSTG LEKTNSQKEL ENENHNYHIG FESSFPSIYP
SFSTDFMPRE ENKRSTNINV VEPSLMLFKG SFLPRMSEST WPKNIEQIGS SIQLVEMPQG
SNMSLASFCN KVKSDHTLGS HKIFQKDKSV IQLNLQKNRE APGKLSRKKN VNDIIEEVKN
ICSVLGCVET KQITDAVNEL NQILQRKAEN FHQNSETSAK GLIEKVTTEL STSIYQLIDV
YCSSFYADFH PLNTPDSVSF VNPGLHSHLS FTVYAAHNIP EIWVHSFPDQ EIRKVAVQQL
DNLLNDELLE YLPQLVQAVK FEWNLESPLV QLLLHRSLQS IQIAHRLYWL LKDAQNEAYF
KSWYQKLLAA LQFCAGKALS DEFAKEMKLI KILGDIGEKV KSASDPQRQA CSYFISNAFP
LKITFFNANP MGKNISIIFK VGDDLRQDML VLQIIQVMDN IWLQEGLDMQ MIIYRCLATG
KGQGLVQMVP DAVTLAKIHQ HSGLIGPLKE NTIKKWFSQH NHLRADYEKA LKNFFYSCAG
WCVVTFILGV CDRHNDNIML TKSGHMFHID FGKFLGEKFL DNRPKVQLVI SYEDVKLTIL
VKHMKNIHLP DGSAPSAHVE FYLLPYPSEV RRRKTKSVPK CTDPTYNEIV VYDEVTELQG
HVLMLIVKSK NTFVGAINIQ LCSVLLNEEK WYPLGNSII
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