ID L5KQE8_PTEAL Unreviewed; 966 AA.
AC L5KQE8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Neutral alpha-glucosidase AB {ECO:0000313|EMBL:ELK13445.1};
GN ORFNames=PAL_GLEAN10011478 {ECO:0000313|EMBL:ELK13445.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13445.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR EMBL; KB030625; ELK13445.1; -; Genomic_DNA.
DR AlphaFoldDB; L5KQE8; -.
DR STRING; 9402.L5KQE8; -.
DR eggNOG; KOG1066; Eukaryota.
DR InParanoid; L5KQE8; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06603; GH31_GANC_GANAB_alpha; 1.
DR CDD; cd14752; GH31_N; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF162; NEUTRAL ALPHA-GLUCOSIDASE AB; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|RuleBase:RU361185};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..966
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003969443"
FT DOMAIN 89..346
FT /note="Glycoside hydrolase family 31 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13802"
FT DOMAIN 409..736
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 744..832
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
FT REGION 210..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 108950 MW; F20A9D4166840909 CRC64;
MAAVPAVAAR RRRSRAGLVL ACLGVCLGIT LAVDRSNFKT CEESSFCRRQ RSIRPGLSPY
RALLDSLQLG PDALTVHLIN EVTKVLLVLE LQGLQKNMTR IRIDELEPRR PRYRVPDVLV
ADPPTARLSV SGRDDNSVEL TVAEGPYKII LTARPFRLDL LEDRSLLLSV NARGLLAFEH
QRAPRVSFSD KVSLTLGSIW DKIKNLFSRQ GSKDPAEGDG AQPEETPGDG DKAKETQGKA
EKDEPGAWEE TFKTHTDTKP YGPTSVGLDF SLPGMEHVYG IPEHADNLRL KVTEGGEPYR
LYNLDVFQYE LYNPMALYGS VPVLLGHSPH RDLGIFWLNA AETWVDISSN TAGKTLFGKM
LDYLQGSGET PQTDVRWMSE SGIIDVFLLL GPSVFDIFRQ YASLTGTQAL PPLFSLGYHQ
SRWNYRDEAD VLEVSQGFDD HNLPCDVIWL DIEHADGKRY FTWDSSRFPQ PLTMLEHLAS
KKRKLVAIVD PHIKVDSGYR IHEELQSLHL YVKTRDGFDY EGWCWPGAAS YPDFTNPTMR
AWWANMFSFD NYEGSAPNLY VWNDMNEPSV FNGPEVTMLK DAKHYGGWEH RDVHNIYGLY
VHMATAEGLV LRSGGVERPF VLSRAFFSGS QRYGAVWTGD NTAEWDHLKI SIPMCLSLGL
VGISFCGADV GGFFKNPAPE LLVRWYQMGA YQPFFRAHAH LDTGRREPWL LPSQYQDIIR
DALDQRYALL PFWYTLLYQA HREGIPVMRP LWVHYPQDVT TFSIDDQFLL GDALLVHPVS
DSGAHGVQVY LPGQGEVWYD VHSYQKHHGP QTLYLPVTLS SIPAFQRGGT IIPRWMRVRR
SSECMKEDPI TLFVALSPQG TAQGELYLDD GHTFNYQTRH EFLLRRFSFS GNTLVSSSAD
PKGHFETPVW IERVVIIGAG KPAAVVLQTK GSPESHLSFQ HDPETSVLIL RKPGVNVASD
WSIHLR
//
