ID   L5KQU6_PTEAL            Unreviewed;       771 AA.
AC   L5KQU6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   SubName: Full=Protein ECT2 {ECO:0000313|EMBL:ELK13615.1};
GN   ORFNames=PAL_GLEAN10012874 {ECO:0000313|EMBL:ELK13615.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK13615.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
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DR   EMBL; KB030623; ELK13615.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KQU6; -.
DR   STRING; 9402.L5KQU6; -.
DR   eggNOG; KOG3524; Eukaryota.
DR   InParanoid; L5KQU6; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR   CDD; cd01229; PH_Ect2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR026817; Ect2.
DR   InterPro; IPR049396; ECT2_BRCT0.
DR   InterPro; IPR049395; ECT2_PH.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR   PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR   Pfam; PF21243; ECT2_BRCT0; 1.
DR   Pfam; PF21242; ECT2_PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT   DOMAIN          309..498
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          247..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          713..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  87194 MW;  8D8B540660FFF2C4 CRC64;
     MADDSGLTST TGRTSLADSS IFDSKVTETS KENLFIGPTS YVEEEMPQIE TRVILVQEAA
     KQEELINALK TIKIMDVPVI KIKETCPGKS DEKLIKTVVN MEIKVPFVKM ESVEEFESLD
     SPEFENVFIV MDFQDPVFHE LYKTDCRVIG PPVVLNCAQK GEPLPFSCRP LYCTSMMNLV
     LCFTGFRKKE ELWFWGSIQM DARAGETMYL YEKANTPELK KSVSLLSLNT PNSNRKRRRL
     KETLAQLSRE TDLSPFPPRK RPSAEHSLSI GSLLDISNTP ESSINYGETP KSCTKSSKNS
     TPLPSKQSAR WQVAKELYQT ESNYVNILAT IIQLFQIPLE EEGQRGGPIL APEEIKTIFG
     SIPDIFDVHT KIKDDLEDLI VNWDESKSIG DIFLKYSKDL IKTYPPFVNF FEMSKETIIK
     CEKQKPRFHA FLKINQAKPE CGRQSLVELL IRPVQRLPSV VLLLNDLKKH TAEENPDKST
     LEKAIGSLKE VMTHINEDKR KTEAQKQIFD VVYEVDGCPA NLLSSHRSLI QRVETISLGE
     HPCDRGEQVT LFLFNDCLEI ARKRHKVIGT FRSPPGHTRP PASLKHIHLM PLSQIKKVLD
     IRETEDCHNA FALLVRPPTE QANVLLSFQM TSEELLKENW LKMLCRHVAN TICKADAENL
     IYTADPESFE VNTKDMDSTL SRASRAIKKT SKKVTRAFSF SKTPKRALRR VLMTSQSSVE
     GRSPSSSDKH VMSRLSSTSS LAGIPSPSLV SLPSFFERRS HTLSRSTTNL I
//