ID   L5KU67_PTEAL            Unreviewed;       966 AA.
AC   L5KU67;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=SH3 domain-binding protein 4 {ECO:0000313|EMBL:ELK14358.1};
GN   ORFNames=PAL_GLEAN10006388 {ECO:0000313|EMBL:ELK14358.1};
OS   Pteropus alecto (Black flying fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC   Pteropodinae; Pteropus.
OX   NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK14358.1, ECO:0000313|Proteomes:UP000010552};
RN   [1] {ECO:0000313|Proteomes:UP000010552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23258410; DOI=10.1126/science.1230835;
RA   Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA   Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA   Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA   Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA   Wang J.;
RT   "Comparative analysis of bat genomes provides insight into the evolution of
RT   flight and immunity.";
RL   Science 339:456-460(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
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DR   EMBL; KB030575; ELK14358.1; -; Genomic_DNA.
DR   AlphaFoldDB; L5KU67; -.
DR   STRING; 9402.L5KU67; -.
DR   eggNOG; ENOG502QTUW; Eukaryota.
DR   InParanoid; L5KU67; -.
DR   Proteomes; UP000010552; Unassembled WGS sequence.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR   PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   4: Predicted;
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW   Membrane {ECO:0000256|ARBA:ARBA00023176};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010552};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          55..114
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          317..454
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          654..724
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   966 AA;  107080 MW;  408A0F11AA802964 CRC64;
     MAAQRIRAAN SSGLPRCRSE GTLIDLSDGF SEASFNDVKV PSPSALLGDN PTPFGNAKEV
     IAIKDYRPDN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS
     DSGLIDNLPE APDEVAKELD LLGGWTEDKK GSGKTYSNNP FWNGVQTNPF LNGNVPAVPG
     VDELTPRSAV DLLLFDTGTP SFTESSSATT NSTGNIFDEL PAAHQLHAEP PARRDNPFFR
     SKRSYSLSEL SVLQANSDAP ASSGFFTGLK SPAPEQFQSR EDFRAAWLSH RKLARSCHDL
     DLLGQSPGWG QTQAVETNIV CKLDSSGGSV QLPDTSISIH VPEGHVAAGE TQQVSMKALL
     DPPLGLNSDR CSSVSPVLEV KLSTLEVRTF LVLEMKVSAE VKNDIFSKST VGLQCLRSDL
     KEGPYVPVPL TCSYGDTVQV HLDNLEPCMY LAMVAHGPNI LYPSTVWDFI HKKVTVGLYG
     PKHIHPSFKT VVTVFGHDCA PKTLLVSEVT RQAPSPAPVA LQLWGKHQFV LSRPQDLQVC
     MFSNMTNYEV RAAEQAKVVR GFQVKLGKVS RLIFPIACQN PGELSDFTLR VQVKDDQDAL
     LTQFCVQTPQ PPPKSALKPS GPRRFLKKNE VGKIILSPFA ATTKYPTFQD RPLSSLKFGK
     LLKTVVRQSK NHYLLEYKKG DAVALLSEEK VRLRGQLWTK EWYIGYYQGR VGLVHARNVL
     VVGRARPSLL AGPELSTSVL LEQILRPCKF LTYIYASVRT LLMENVSSWR SFADALGYGD
     LPLTFFCRAE LDSEPERVAS VLEKLKEDCN NMDSKDRKSF QKELMMALLK MDCQGLVVRL
     LQDFVLLTTA VEVAQRWREL AEKLAKVSKQ QMDAYESPHR DRNGVVDSEV SGLGQQQLLP
     GVFVRTERVT GPYRDVIQEL HTGLDRMKNP ITKRWKHLTG TLILVNCLDV LRAAAFSPAD
     QDDFVI
//