ID L5L6W4_PTEAL Unreviewed; 538 AA.
AC L5L6W4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Keratin, type II cytoskeletal 73 {ECO:0000313|EMBL:ELK19001.1};
GN ORFNames=PAL_GLEAN10005089 {ECO:0000313|EMBL:ELK19001.1};
OS Pteropus alecto (Black flying fox).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Megachiroptera; Pteropodidae;
OC Pteropodinae; Pteropus.
OX NCBI_TaxID=9402 {ECO:0000313|EMBL:ELK19001.1, ECO:0000313|Proteomes:UP000010552};
RN [1] {ECO:0000313|Proteomes:UP000010552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; KB030275; ELK19001.1; -; Genomic_DNA.
DR RefSeq; XP_006904620.1; XM_006904558.1.
DR AlphaFoldDB; L5L6W4; -.
DR STRING; 9402.L5L6W4; -.
DR GeneID; 102880710; -.
DR KEGG; pale:102880710; -.
DR eggNOG; ENOG502SK67; Eukaryota.
DR InParanoid; L5L6W4; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000010552; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF31; KERATIN, TYPE II CYTOSKELETAL 73; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000010552}.
FT DOMAIN 132..445
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 503..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 208..235
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 343..423
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 520..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 58828 MW; 68D9A4A7496755D5 CRC64;
MSRQFACKSG VATNRGFSGC SAVLSGDSLS SYQAGGKSLS RSFGSRSLYS LGGARSVSFN
VASGSGRAGS YGFGRSRASG FAGSMFGNVA LGPVCPSVCP PGGIHQVTIN KSLLAPLNVE
LDPEIQKVRS QEREQIKTLN NKFASFIDKV RFLEQQNQVL ETKWELLQQL DLNSCKNNLE
PILEGYISTL RKQLETLSGD RVRLDSELRN MRDVVEDYKM RYEEEVNKRT TAENEFVVLK
KDVDSAYMNK VELQAKVDAL DGEIKFFKCL YEGEIAQIQS HISDTSVILS MDNNRSLDLD
SIITEVRAQY EDIALKSKAE AEALYQTKFQ ELQLAAGRHG DDLKNTKNEI SELIRLIQRL
RSEIESVKKQ CSNLETAIAD AEQRGDCALK DARAKLDELE AALHQAKEEL ARMLREYQEL
MSTKLALDVE IATYRKLLEG EECRMSGEYT NSVSISVISS STAGTAGTGP GFGFSGTGTY
GYRPSSVGYG MLSGGCVTGS GNCSPRGEAK TRLGSTSEFK DLPGKTSALS SPAKKTTR
//
