ID L5LCF7_MYODS Unreviewed; 790 AA.
AC L5LCF7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 5 {ECO:0000313|EMBL:ELK23892.1};
DE Flags: Fragment;
GN ORFNames=MDA_GLEAN10020515 {ECO:0000313|EMBL:ELK23892.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK23892.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB113176; ELK23892.1; -; Genomic_DNA.
DR AlphaFoldDB; L5LCF7; -.
DR eggNOG; KOG1419; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..223
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 305..492
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 284..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELK23892.1"
SQ SEQUENCE 790 AA; 87306 MW; E2A8DADD5942D8EF CRC64;
FLLVFGCLIL SVFSTIPEHT KLASSCLLIL EFVMIVVFGL EFIIRIWSAG CCCRYRGWQG
RLRFARKPFC VIDTIVLIAS IAVVSAKTQG NIFATSALRS LRFLQILRMV RMDRRGGTWK
LLGSVVYAHS KELITAWYIG FLVLIFSSFL VYLVEKDANK EFSTYADALW WGTITLTTIG
YGDKTPLTWL GRLLSAGFAL LGISFFALPA GILGSGFALK VQEQHRQKHF EKRRNPAANL
IQCVWRSYAA DEKSVSIATW KPHLKALHTC SPTNQKLSFK ERVRMASPRG QSIKSRQASI
GDRRSPSTDI TAEGSPTKVQ KSWSFNDRTR FRPSLRLKSS QPKPVVDADT ALGTDDVYDE
KGCQCDVSVE DLTPPLKTVI RAIRIMKFHV AKRKFKETLR PYDVKDVIEQ YSAGHLDMLC
RIKSLQTRVD QILGKGQITS DKKSREKIPA EHETTDDLSM LGRVVKVEKQ VQSIESKLDC
LLDIYQQVLR KGSASALALA SFQIPPFECE QTSDYHSPVD SKDLSSSAQN SGCLTRSASA
NISRGLQFIL TPNEFSAQTF YALSPTMHSQ ATQVPLSQSD GSSVVATNNI ANQINAAPKP
AAPATLQIPP PLPAIKHPPR PETLHPNPTG LQESIPDVTA CLVASKENVQ VAQSNLTRDR
SLRKSFDMGG ETLLSVHPVA PKDLGKSLSV QNLVRSTEEL NIQLSGSESS GSRGSQDFYP
KWRESKLFIT DEELGSEEAE TDAFDAAPQP ARETAFASDS LRTGRSRSSQ SICKAGESTD
ALSLPHVKLK
//
