ID L5LPC8_MYODS Unreviewed; 839 AA.
AC L5LPC8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
GN ORFNames=MDA_GLEAN10024286 {ECO:0000313|EMBL:ELK27931.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK27931.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB109639; ELK27931.1; -; Genomic_DNA.
DR RefSeq; XP_006766716.1; XM_006766653.2.
DR AlphaFoldDB; L5LPC8; -.
DR GeneID; 102773365; -.
DR KEGG; myd:102773365; -.
DR CTD; 80834; -.
DR eggNOG; KOG1056; Eukaryota.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR CDD; cd15288; 7tmC_TAS1R2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK27931.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..839
FT /note="Taste receptor type 1 member 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003970513"
FT TRANSMEM 561..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..831
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 839 AA; 93828 MW; 6CE26D26D51FF371 CRC64;
MGPQAGVVCS LFFLLQALAV PAENPDFSLA GDYLLGGLFT LHANVKGTVH LNFLQVPKCK
EYEVKALGYK LMQAMHFAVE EINNHSSLLP GVRLGYEMVD VCYVSNNIQP VLYFLAQEDY
FLPIQEDYSH YVPRVVAVIG PENSEATMTV AHFLSLFLLP QITFSAISDD LRDKQSFPAV
LRTVPGADHH LEAMVQLMLR FGWNWIVVLV SDDDYGRRNS QLLSEHLARH DICVALHEVL
PTPQPSQVVT RQERRRLEAI VDKLRHSSAR VVVVFSPDLA LHHFFHQVLR QNLTGTVWIA
SESWAIDLAL HNLTELSHTG TFLGVTTESV SIPGFSEFRV RRAQARTPAS NRPSSGATCN
QECDACLAAL ESFNTILTLS GERVAYSVYS AVYAVAHGLH SLLGCSQTHC PKEVVYPWRL
LQEIRKVNFT LLGHHIFFDD HGDLPMPLEV IQWHWNQSQN PFQTIASYHP AQRQLKDVRG
VSWHTPDGTV PVSTCSKDCQ PGQKKKSVGI HPCCFECLDC PPGTFLNKTE DEFDCQPCPS
NEWSHRGDTS CFKRQLTFLQ WHNALTIFVV LLAALGFLGT LAILAIFWRH LQTPMVRSAG
GPMCFLILTS LLVAYLMVPT YVGPPTPATC LCRQTFFTLC FTICISCIAV RSFQIVYVFK
MARQLPRAYG YWVRYHGPYV FVAAITALKV AVVTTNQLIT ATGPTARADP GDPKIMILSC
NPDYSKGLLV NTSLDLLLSV VGFSFAYMGK ELPTSYNEAK FITFCMTFYF TSSISLCTFM
SVYEGVLVTF LDLLVTVLNL LGISLGYFGP KCYLILFHPE RNTPAYFSSV IQGYTMGRD
//
