ID L5LRJ1_MYODS Unreviewed; 125 AA.
AC L5LRJ1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Mitochondrial glutathione transporter SLC25A39 {ECO:0000256|RuleBase:RU369018};
DE AltName: Full=Solute carrier family 25 member 39 {ECO:0000256|RuleBase:RU369018};
GN ORFNames=MDA_GLEAN10009328 {ECO:0000313|EMBL:ELK28706.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK28706.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC into mitochondria. Glutathione, which plays key roles in oxidative
CC metabolism, is produced exclusively in the cytosol and is imported in
CC many organelles. Mitochondrial glutathione is required for the activity
CC and stability of proteins containing iron-sulfur clusters, as well as
CC erythropoiesis. {ECO:0000256|RuleBase:RU369018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glutathione(in) = glutathione(out); Xref=Rhea:RHEA:74819,
CC ChEBI:CHEBI:57925; Evidence={ECO:0000256|ARBA:ARBA00036017};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU369018}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU369018}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU369018}.
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DR EMBL; KB108893; ELK28706.1; -; Genomic_DNA.
DR AlphaFoldDB; L5LRJ1; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; FI19922P1-RELATED; 1.
DR PANTHER; PTHR45760:SF1; MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A39-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
PE 3: Inferred from homology;
KW Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|RuleBase:RU369018};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU369018};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|RuleBase:RU369018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transport {ECO:0000256|RuleBase:RU369018}.
SQ SEQUENCE 125 AA; 13478 MW; 8D0BB44E97CC50DF CRC64;
MADQDTGGIS PLQQMVAPGA GAVVTSTFMT PLDVVKVRLQ SQLPAVTSEL MPPSRLWSLL
RQIALLPPTP REVPPVLQWC PGALGPVPKW CPLCHLHSGP HSLQLVMTVP ATAIYFTTYD
NSRPS
//
