ID L5LUN8_MYODS Unreviewed; 193 AA.
AC L5LUN8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=CD70 antigen {ECO:0000313|EMBL:ELK29806.1};
GN ORFNames=MDA_GLEAN10007265 {ECO:0000313|EMBL:ELK29806.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK29806.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; KB107572; ELK29806.1; -; Genomic_DNA.
DR RefSeq; XP_006764312.1; XM_006764249.2.
DR AlphaFoldDB; L5LUN8; -.
DR GeneID; 102751991; -.
DR KEGG; myd:102751991; -.
DR CTD; 970; -.
DR eggNOG; ENOG502TEKD; Eukaryota.
DR OrthoDB; 5255922at2759; -.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR042374; CD70.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15152; CD70 ANTIGEN; 1.
DR PANTHER; PTHR15152:SF0; CD70 ANTIGEN; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..188
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 193 AA; 21581 MW; 14E9D49B54528AE9 CRC64;
MEMAEEGCAR RLRHLLMAPV LRVVLPLSFL GLIIVCVLCC RLPAQQQLLQ PPEWDVAEFQ
LNHTGLRQDP RLHWQGGPAL GRSFLHGPQL DNGQLRVQRD GIYRLHIQVT LTNCSSSVKN
IVSRRAVLAV GICSPVARSV SLLRLNFHLS CTVSSQRLTY LAHGDTLCTN LTLPLLPSQN
SDETFLGVQW VHH
//
