ID L5M122_MYODS Unreviewed; 1000 AA.
AC L5M122;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=MHC class II regulatory factor RFX1 {ECO:0000313|EMBL:ELK32046.1};
GN ORFNames=MDA_GLEAN10004551 {ECO:0000313|EMBL:ELK32046.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK32046.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KB105657; ELK32046.1; -; Genomic_DNA.
DR AlphaFoldDB; L5M122; -.
DR eggNOG; KOG3712; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF23; MHC CLASS II REGULATORY FACTOR RFX1; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 424..499
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..924
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 107617 MW; 95C8503F306B6A33 CRC64;
MATQAYVTEL QATPQPSQPP QAQPQPPPSA APQPPQPPAT AATPQPQYVT ELQSPQPQTQ
PPGSQKQYVT ELPAAPTPSQ PAGTPAPSSV SQQYIVVTVS EGAMRASETV SEASPGSTAS
QTGVPTRLSF LPPQRLLVQS SVQTKPGHMS PLQLTNIPVP PQALPTQRLV VQSTAPGVKA
GQVSLTVHGT QQVHSPPERS PVQANSSSSK TAGAPTGTVP QQLQVHGVQQ SVPVTQERSV
VQATPQAPKA SPVQPLTVQG LQPVHVAQEV QQLQQVPVPH VYSSQVQYVE GGDASYTTSA
IRSSTYPYPE TPLYTQTAGT SYYEAAGTAA QVSTPATSQA VASSGSVPMY VSGSQVVASP
TSSGGGASNS SNGGSGGNGA GGGGSGGGSS GSSSGAGTYV IQGGYMLGSA SQSYSHTTRA
SPATVQWLLD NYETAEGVSL PRSTLYCHYL LHCQEQKLEP VNAASFGKLI RSVFMGLRTR
RLGTRGNSKY HYYGLRIKAS SPLLRLMEDQ QHMAMRGQPF SQKQRLKPIQ KMEGMTNGVA
VGPQQATGLS DISAQVQQYQ QFLDASRSLP DFSELDIQGK VLPEGIGPGD IKAFQVLYRE
HCEAIVDVMV NLQFTLVETL WKTFWRYNLN QSSEAPPLAV HDEAEKRLPK ASLVLLSKFE
PVLQWTKHCD NVLYQGLVEI LIPDVLRPIP SALTQAIRNF AKSLESWLTH AMVNIPEEML
RVKVAAAGAF AQTLRRYTSL NHLAQAARAV LQNTAQINQM LSDLNRVDFA NVQEQASWVC
RCEDRVVQRL EQDFKVTLQQ QNSLEQWAAW LDGVVSQVLK PYQGSTGFPK AAKLFLLKWS
FYSSMVIRDL TLRSAASFGS FHLIRLLYDE YMYYLIEHRV AQAKGETPIA VMGEFPNLAT
SLNPLDPDKD EEEEEEEESE DELPQDISLA AGSESPSPAL GPEALEPPTK LARTDTRGPW
PGWGGGLPDR EVKGVPPPTG PAQSQGRVKP QLQTDTQDVP
//
