ID L5M4L3_MYODS Unreviewed; 602 AA.
AC L5M4L3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Pleckstrin like proteiny domain-containing family G member 7 {ECO:0000313|EMBL:ELK33564.1};
GN ORFNames=MDA_GLEAN10011249 {ECO:0000313|EMBL:ELK33564.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33564.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
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DR EMBL; KB104095; ELK33564.1; -; Genomic_DNA.
DR AlphaFoldDB; L5M4L3; -.
DR eggNOG; KOG3521; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13245; PH_PLEKHG7; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF15720; DUF4675; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010556}.
FT DOMAIN 199..399
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 446..579
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 68838 MW; 9560806D9A50DFA8 CRC64;
MGKTEQSHPE QPQSLEACPL HPQGGLSRKP CEKQGSLLHF DRQAPGRIST SPTLRRLRGN
GCGTRHSLPQ QETVEEPTWG GRKEPAGSPY YLSQSLPASP QNSSHSLSTL RLGSRLPPDP
KRILTTTDSS EPPTRPTDEA AFPVLRPVHE GSLPDTPLPG RGSRSPSPAA QLPGPQGKTW
NEVMATHRKL PTDQVDLRKQ QEAVWELFAS ECTYFLDHLL VLKMIFMNTL KYLQTYEYLL
DVDSWRLFAN LEELSQTSYG FASSLFAIIK DYFDASETSP PMDFISVLAK HFRGSLCQSH
QTYCLNYSAA VFYLESLKQR EDFGIYLKWC EQNEQCRRLH LAELLVAPLH RLTRYPLLLK
NIWKRSTDST EKIMIYSIKE KVEKSIRDLE GKVKWLDNFQ KFRHLQEIIV WPPLWDRDKR
FFIPECLKHI FKEHMAENIL SPTNRHLLYE GKLTLAESTR FLDVYLFLFD DFLLVTKTKR
NKKKVGGLDT GVMCPSLTPE LQTVIKEGGS CKVLDQPIPL DRLVVKSIDP LHVSVFGLRN
AFLIQHESRY RQCIAAFLLQ AQTENIKKTW MAQITAAISC FTKSQETKKI SLFRSSTESS
EI
//
