ID L5M6F9_MYODS Unreviewed; 2421 AA.
AC L5M6F9;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|EMBL:ELK33907.1};
GN ORFNames=MDA_GLEAN10012598 {ECO:0000313|EMBL:ELK33907.1};
OS Myotis davidii (David's myotis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=225400 {ECO:0000313|EMBL:ELK33907.1, ECO:0000313|Proteomes:UP000010556};
RN [1] {ECO:0000313|Proteomes:UP000010556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23258410; DOI=10.1126/science.1230835;
RA Zhang G., Cowled C., Shi Z., Huang Z., Bishop-Lilly K.A., Fang X.,
RA Wynne J.W., Xiong Z., Baker M.L., Zhao W., Tachedjian M., Zhu Y., Zhou P.,
RA Jiang X., Ng J., Yang L., Wu L., Xiao J., Feng Y., Chen Y., Sun X.,
RA Zhang Y., Marsh G.A., Crameri G., Broder C.C., Frey K.G., Wang L.F.,
RA Wang J.;
RT "Comparative analysis of bat genomes provides insight into the evolution of
RT flight and immunity.";
RL Science 339:456-460(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB103531; ELK33907.1; -; Genomic_DNA.
DR eggNOG; KOG3533; Eukaryota.
DR Proteomes; UP000010556; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF3; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR SMART; SM00472; MIR; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELK33907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010556};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 2080..2108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2129..2151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2256..2279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..167
FT /note="MIR"
FT /evidence="ECO:0000259|SMART:SM00472"
FT DOMAIN 185..293
FT /note="MIR"
FT /evidence="ECO:0000259|SMART:SM00472"
FT REGION 215..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2352..2400
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1047..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2421 AA; 276429 MW; 431BA2FA2768743C CRC64;
MAIRNVGKEE DILNRANQLG ITEHQEMNCS LDILKPWPEL VDDRCVVHPE AGDLANPPKK
FRDCLFKVCP MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ NESENKKLLG
EIVKYSNVIQ SNLTVNKRLP ALLEKNAMRV SLDAAGNEGS WFYIHPFWKL RSEGDNVVHH
DPCRGGAGQW NSLFRFKHLA TGNYLAAELN PDYRDAQNEG KNVRDGDLPT SKKKRQAGEK
IMYTLVSVPH GNDIASLFEL DATTLQRADC LVPRNSYVRL RHLCTNTWVT STSIPIDTDE
ERPVMLKIGT CQTKEDKEAF AIVSVPLSEV RDLDFANDAN KVLATTVKKL ENGTITQNER
RFVTKLLEDL IFFVADVLNN GQEVLDVVIT KPNRERQKLM REQNILAQVF GILKAPFKEK
AGEGPMLRLE DLGDQRYAPY KYMLRLCYRV LRHSQQDYRK NQEYIAKNFC VMQSQIGYDI
LAEDTITALL HNNRKLLEKH ITAKEIETFV SLLRRNREPR FLDYLSDLCV SNTTAIPVTQ
ELICKFMLSP GNADILIQTK LVSMQMDNPL ESSILSDDID DEEVWLYWID SNKEPHGKAI
RHLAQEAKEG TKADLEVLTY YRYQLNLFAR MCLDRQYLAI NQISTQLSVD LILRCMSDES
LPFDLRASFC RLMLHMHVDR DPQESVVPVR YARLWTEIPT KITIHEYDSI TDCSRNDMKR
KFALTMEFVE EYLKEVVNQP FPFGDKEKNK LTFEVVHLAR NLIYFGFYSF SELLRLTRTL
LAILDIVQVP MSSYFERLSK FQDGGNNVMR TIHGVGEMMT QMVLSRGSIF PMSVPDVQPS
IHPSKQGSPA EQEDVTVMDT KLKIIEILQF ILSVRLDYRI SYMLSIYKKE FGESNENAET
SANGSPDTLI PAAIVPDIDE IAAQAETMFA GRKEKNPVQL DDEGGRTFLR VLIHLIMHDY
PPLLSGALQL LFKHFSQRSE VLQAFKQVQL LVSNQDVDNY KQIKADLDQL RLTVEKSELW
VEKSSSYENG EMGENQVKGG EEPIEESNNL SPVQDGTRIP QIDSNKSNNY RIVKEILIRL
SKLCIQNKKC RNQHQRLLKN MGAHSVVLDL LQIPYEKLLE AETMRHIFMN NYHLCNEISE
RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD GKYVKKCQDM IMTELINGGE DVLIFYNDRA
SFPILLHMMC SERDRGDESG PLAYHITLVE LLAACTEGKN VYTEIKCNSL LPLDDIVRVV
THDDCIPEVK VAYVNFVNHC YVDTEVEMKE IYTSNHIWKL FENFLVDMAR VCNTTTDRKH
ADTSLEKCVT ESIMSIVSGF FNSPFSDNST SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK
ASVESCIRTL AEVAKNRGIA IPVDLDSQVN TLFMKNHSNM VQRAAMGWRL SARSGPRFKE
ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM MQAEFSVLVD VLYSPELLFP EGSDARIRCG
AFMSKLINHT KKLMEKEEKL CIKILQTLRE MLEKKDIFVE EGNTLRKILL NRYFKGDYGV
GINGHLSGTY SKSAPGGGNF SGQDSDKMGI SMSDIQCLLD KEGASELVID VIVNTKNDRI
FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ KRSEKFFKVL YDRMKAAQKE IRSTVTVNTI
DLGNKKRDDD NELMTSGPRM RVRDSSLHLK EGMKGQLTEA SSATSKAYCV YRREMDPEID
IMCTGSEGSN AEDKSAEEVT MSPAIAIMQP ILRFLQLLCE NHNRELQNFL RNQNNKTNYN
LVCETLQFLD CICGSTTGGL GLLGLYINEK NVVLVNQTLE SLTEYCQGPC HENQTCIATH
ESNGIDIIIA LILNDINPLG KYRMDLVLQL KNNASKLLLA IMESRHDSEN AERILFNMRP
RELLARHNKL LQQMLKPGSD PDDGDEALKY YANHTAQIEI VRHDRTMEQI VFPVPNICEY
LTRESKCRVF TMTERDEQGS KVNDFFQQTE DLYNEMKWQK KIRTYVSPKK KPVRKLRYEA
KLGVAEAAAL CNKIVFLVSF VGNRGTFTRG YRAVILDMAF LYHVAYVLVC MLGLFVHEFF
YSFLLFDLVY REETLLNVIK SVTRNGRSII LTAVLALILV YLFSIIGFLF LKDDFTMEVD
RLKNRTPITG SNDVPTMTLT SMMGTCDKGN CSPTIPASNT ADEEYEDGIE RTCDTLLMCI
VTVLNQGLRN GGGVGDVLRR PSKDEPLFAA RVVYDLLFYF IVIIIVLNLI FGVIIDTFAD
LRSEKQKKEE ILKTTCFICA QGSPSEIAKQ RSKVRYVLES KFPGSVRSGF KGAILGKRKE
KNLDWFPRMR AMSLVSNEGD SEQNEIRNLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN
KQRLGFLGSN TPHVNHHMPP H
//
